1-(3-chlorophenyl)biguanide hydrochloride

Modify Date: 2025-08-25 22:07:59

1-(3-chlorophenyl)biguanide hydrochloride Structure
1-(3-chlorophenyl)biguanide hydrochloride structure
 Common Name 1-(3-chlorophenyl)biguanide hydrochloride
CAS Number 2113-05-5 Molecular Weight 248.11
Density 1.49g/cm3 Boiling Point 434.1ºC at 760mmHg
Molecular Formula C8H11Cl2N5 Melting Point 190-194 °C(lit.)
MSDS Chinese USA Flash Point 216.3ºC
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 1-(3-chlorophenyl)biguanide hydrochloride


m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1].

 Names

Name 2-(3-chlorophenyl)-1-(diaminomethylidene)guanidine,hydrochloride
Synonym More Synonyms

  Biological Activity

Description m-CPBG (1-(3-Chlorophenyl)biguanide) hydrochloride is a selective 5-HT3 agonist. m-CPBG hydrochloride can be used for the research of neurological disease[1].
Related Catalog
In Vivo m-CPBG hydrochloride (80 and 160 nM) 显著减少急性盐负荷引起的水摄入量[1]。 m-CPBG hydrochloride (third ventricle injection; 160 nM) 显著抑制低血容量动物的水摄入[1]。 m-CPBG hydrochloride (third ventricle injection; 320 nM) 减少缺水大鼠的水摄入量[1]。 m-CPBG hydrochloride (central administration） 抑制中枢胆碱能和血管紧张素能通路药理学激活诱导的水摄入[1]。 Animal Model: Wistar male rats[1] Dosage: 80, 160 and 320 nM Administration: Ventricle injection Result: Decreased water intake induced by water deprivation, acute salt load and hypovolemia.
References

[1]. Castro L, et al. Central 5-HT(3) receptors and water intake in rats. Physiol Behav. 2002;77(2-3):349-359.  

 Chemical & Physical Properties

Density 1.49g/cm3
Boiling Point 434.1ºC at 760mmHg
Melting Point 190-194 °C(lit.)
Molecular Formula C8H11Cl2N5
Molecular Weight 248.11
Flash Point 216.3ºC
Exact Mass 247.03900
PSA 97.78000
LogP 3.33540
Appearance of Characters solid | white
Vapour Pressure 9.74E-08mmHg at 25°C
Storage condition Desiccate at RT
Water Solubility H2O: soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DU1780000
CHEMICAL NAME :
Biguanide, 1-(m-chlorophenyl)-, monohydrochloride
CAS REGISTRY NUMBER :
2113-05-5
LAST UPDATED :
199007
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H10-Cl-N5.Cl-H
MOLECULAR WEIGHT :
248.14
WISWESSER LINE NOTATION :
MUYZMYUM&MR CG &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
186 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 10,521,1967
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
350 mg/kg
TOXIC EFFECTS :
Endocrine - hyperglycemia
REFERENCE :
IJOCAP Indian Journal of Chemistry. (New Delhi, India) V.1-13, 1963-75. Divided into Indian Journal of Chemistry, Section A and Indian Journal of Chemistry, Section B. Volume(issue)/page/year: 1,218,1962

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DU1780000

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 Synonyms

1-(3-Chlorophenyl)biguanide hydrochloride
m-Chlorophenylbiguanide hydrochloride
MFCD00053019
N-m-Chlorophenylbiguanide hydrochloride
m-CPBG hydrochloride
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Chemsrc provides CAS#:2113-05-5 MSDS, density, melting point, boiling point, structure, etc. Its name is 1-(3-chlorophenyl)biguanide hydrochloride>> amp version: 1-(3-chlorophenyl)biguanide hydrochloride

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