CCT 365623 hydrochloride
Modify Date: 2024-01-09 10:54:52
CCT 365623 hydrochloride structure
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Common Name | CCT 365623 hydrochloride | ||
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| CAS Number | 2126136-98-7 | Molecular Weight | 443.975 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C18H18ClNO4S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of CCT 365623 hydrochlorideCCT 365623 (CCT365623) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM; inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF, also activates SMAD2 and downregulates MATN2; delays the growth of primary and metastatic tumour cells in vivo. |
| Name | CCT 365623 hydrochloride |
|---|
| Description | CCT 365623 (CCT365623) hydrochloride is a potent, orally active small molecule inhibitor of lysyl oxidase (LOX) with IC50 of 0.89 uM; inhibits LOX actvity in living cell system (MDCK cysts) at 5 uM, reduces EGFR retention at the cell surface, suppresses EGFR and AKT phosphorylation driven by EGF, also activates SMAD2 and downregulates MATN2; delays the growth of primary and metastatic tumour cells in vivo. |
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| References | References 1. Tang H, et al. Nat Commun. 2017 Apr 18;8:14909. View Related Products by Target Other Targets |
| Molecular Formula | C18H18ClNO4S3 |
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| Molecular Weight | 443.975 |