2,2′-Dipyridyl disulfide

Modify Date: 2025-08-25 20:36:37

2,2′-Dipyridyl disulfide Structure
2,2′-Dipyridyl disulfide structure
 Common Name 2,2′-Dipyridyl disulfide
CAS Number 2127-03-9 Molecular Weight 220.31
Density 1.3±0.1 g/cm3 Boiling Point 356.1±17.0 °C at 760 mmHg
Molecular Formula C10H8N2S2 Melting Point 56-58 °C(lit.)
MSDS Chinese USA Flash Point 169.2±20.9 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of 2,2′-Dipyridyl disulfide


2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].

 Names

Name 2-(pyridin-2-yldisulfanyl)pyridine
Synonym More Synonyms

 2,2′-Dipyridyl disulfide Biological Activity

Description 2,2′-Dipyridyl disulfide is a useful reagent for the determination of sulfhydryl groups. 2,2′-Dipyridyl disulfide is a common reagent in peptide chemistry, often used in oxidation–reduction condensations to form peptide bonds or in coupling reactions to form disulfide-linked heterodimers[1].
Related Catalog
In Vitro Formation of intramolecular S–S bonds can be dramatically accelerated by addition of a 2,2′-Dipyridyl disulfide (2-PDS) solution to an air-oxidized mixture of cysteine-containing peptides[1].
References

[1]. K Maruyama, et al. 2,2'-Bispyridyl disulfide rapidly induces intramolecular disulfide bonds in peptides. Peptides. 1999;20(7):881-4.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 356.1±17.0 °C at 760 mmHg
Melting Point 56-58 °C(lit.)
Molecular Formula C10H8N2S2
Molecular Weight 220.31
Flash Point 169.2±20.9 °C
Exact Mass 220.012894
PSA 76.38000
LogP 2.53
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.694
Storage condition 2-8°C
Water Solubility 5 g/L (20 ºC)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn:Harmful;
Risk Phrases R20/22;R37
Safety Phrases S36/37/39-S37/39-S25-S22
RIDADR UN3335 9
WGK Germany 3

 Synthetic Route

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 Synonyms

di(2-pyridyl) disulfide
Bis(2-pyridinyl) disulfide
2,2'-Dipyridyl disuldide
pyridyl disulfide
2,2'-Dipyridyl disulfide
2-Pyridinyl disulfide
2,2'-DIHYDROXYDIPHENYLMETHANE
2,2'-Dithiobispyridine
1,2-Di(pyridin-2-yl)disulfane
2-Pyridin-2-yldisulfanylpyridine
MFCD00006287
EINECS 218-343-1
2,2‘-Dithiodipyridine
2-Dipyridyl disulfide
Aldrithiol 2
2,2′-dipyridyldisulfide
bis-pyridin-2-yl-disulfide
pyridyldisulfide
2,2'-Disulfanediyldipyridine
Aldrithiol
Bis(2-pyridyl) disulfide
2,2′-dipyridyl disulfide
Pyridine, 2,2'-dithiobis-
Aldrithiol™-2
2,2'-dipyridinyl disulfide
2,2'-Dithiodipyridine
4,4′-dipyridyldisulfide
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