eIF4A3-IN-1q
Modify Date: 2025-09-18 18:58:45
eIF4A3-IN-1q structure
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Common Name | eIF4A3-IN-1q | ||
|---|---|---|---|---|
| CAS Number | 2132392-89-1 | Molecular Weight | 645.861 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C29H21BrClF3N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of eIF4A3-IN-1qA potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM; displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM); upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM) ; shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss. |
| Name | eIF4A3-IN-1q |
|---|
| Description | A potent, subtype-selective, orally available eIF4A3 inhibitor with IC50 of 0.14 uM; displays no activity against eIF4A1, eIF4A2, BRR2 and DHX29 (IC50>100 uM); upregulates SC35 1.6 kb mRNA expression by 8-fold at 3 uM and 20-fold at 10 uM, potently inhibit cell growth in HCT-116 cells (GI50=1.18 uM) ; shows antitumor efficacy and promising PK profiles in vivo, without severe body weight loss. |
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| References | References 1. Mizojiri R, et al. ACS Med Chem Lett. 2017 Sep 8;8(10):1077-1082. View Related Products by Target Eukaryotic Initiation Factor (eIF) |
| Molecular Formula | C29H21BrClF3N4O3 |
|---|---|
| Molecular Weight | 645.861 |
| InChIKey | GODSKPATKZSZMU-RUZDIDTESA-N |
| SMILES | O=C(c1cc(C(F)(F)F)c(=O)n(-c2ccccc2)c1)N1CCN(C(=O)c2ccc(Br)cn2)C(c2ccc(Cl)cc2)C1 |