USP25 and 28 inhibitor AZ-1

Modify Date: 2024-01-03 10:31:49

USP25 and 28 inhibitor AZ-1 Structure
USP25 and 28 inhibitor AZ-1 structure
Common Name USP25 and 28 inhibitor AZ-1
CAS Number 2165322-94-9 Molecular Weight 422.21
Density N/A Boiling Point N/A
Molecular Formula C17H16BrF4NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of USP25 and 28 inhibitor AZ-1


USP25/28 inhibitor AZ1 (AZ1) is a potent, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 reduces cell viability across a range of cancer cell lines[1].

 Names

Name USP25/28 inhibitor AZ1

 USP25 and 28 inhibitor AZ-1 Biological Activity

Description USP25/28 inhibitor AZ1 (AZ1) is a potent, selective, noncompetitive, dual ubiquitin specific protease (USP) 25/28 inhibitor with IC50s of 0.7 μM and 0.6 μM, respectively. USP25/28 inhibitor AZ1 reduces cell viability across a range of cancer cell lines[1].
Related Catalog
Target

IC50: 0.7 nM (USP25) and 0.6 nM (USP28)[1]

References

[1]. Wrigley JD, et al. Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating EnzymeSubfamily. ACS Chem Biol. 2017 Dec 15;12(12):3113-3125.

 Chemical & Physical Properties

Molecular Formula C17H16BrF4NO2
Molecular Weight 422.21
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