eprodisate

Modify Date: 2024-01-02 19:29:04

eprodisate Structure
eprodisate structure
Common Name eprodisate
CAS Number 21668-77-9 Molecular Weight 204.222
Density 1.8±0.1 g/cm3 Boiling Point N/A
Molecular Formula C3H8O6S2 Melting Point 120-124ºC
MSDS Chinese USA Flash Point N/A
Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger

 Use of eprodisate


Eprodisate is a new compound designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues[1]. Eprodisate slow the progression of AA amyloidosis-related renal disease and has possible applicability to other types of amyloidosis[2].

 Names

Name propane-1,3-disulfonic acid
Synonym More Synonyms

 eprodisate Biological Activity

Description Eprodisate is a new compound designed to interfere with interactions between amyloidogenic proteins and glycosaminoglycans and thereby inhibit polymerization of amyloid fibrils and deposition of the fibrils in tissues[1]. Eprodisate slow the progression of AA amyloidosis-related renal disease and has possible applicability to other types of amyloidosis[2].
Related Catalog
References

[1]. Dember LM, et al. Eprodisate for the treatment of renal disease in AA amyloidosis. N Engl J Med. 2007 Jun 7;356(23):2349-60.

[2]. Manenti L, et al. Eprodisate in amyloid A amyloidosis: a novel therapeutic approach? Expert Opin Pharmacother. 2008 Aug;9(12):2175-80.

 Chemical & Physical Properties

Density 1.8±0.1 g/cm3
Melting Point 120-124ºC
Molecular Formula C3H8O6S2
Molecular Weight 204.222
Exact Mass 203.976227
PSA 125.50000
LogP -3.47
Index of Refraction 1.549

 Safety Information

Symbol GHS05 GHS07
GHS05, GHS07
Signal Word Danger
Hazard Statements H302 + H312 + H332-H314
Precautionary Statements P280-P305 + P351 + P338-P310
Hazard Codes Xi: Irritant;C: Corrosive;
Risk Phrases 36/37/38-34-20/21/22
Safety Phrases S26-S36-S45-S36/37/39-S27
RIDADR 3265
WGK Germany 3
Packaging Group III
Hazard Class 8
HS Code 2904100000

 Synthetic Route

~88%

eprodisate Structure

eprodisate

CAS#:21668-77-9

Literature: Tetrahedron Letters, , vol. 48, # 46 p. 8178 - 8181

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eprodisate Structure

eprodisate

CAS#:21668-77-9

Literature: Journal of the American Chemical Society, , vol. 67, p. 1578,1580 Journal of the American Chemical Society, , vol. 58, p. 488

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eprodisate Structure

eprodisate

CAS#:21668-77-9

Literature: Chemische Berichte, , vol. 91, p. 1512,1514

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eprodisate Structure

eprodisate

CAS#:21668-77-9

Literature: Kogyo Kagaku Zasshi, , vol. 59, p. 221,223 Chem.Abstr., , p. 10362

 Customs

HS Code 2904100000
Summary 2904100000 derivatives containing only sulpho groups, their salts and ethyl esters。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

 Synonyms

propanedisulfonate
Propane-1,3-disulfonate
Eprodisate [INN]
eprodisate
1.3-propanesultone
1,3-propane sulfone
Propane-1,3-disulfonic acid
1,3-propanedisulphonic acid
1,3-Propanedisulfonic acid
1,3-Propanedisulfonicacid
UNII-6QFP76V7S7
P8454_ALDRICH
1,3-Propane disulfonate
MFCD00191483