Caerulomycin A

Modify Date: 2026-06-30 11:48:15

Caerulomycin A Structure
Caerulomycin A structure
Common Name Caerulomycin A
CAS Number 21802-37-9 Molecular Weight 229.23500
Density 1.23g/cm3 Boiling Point 400.4ºC at 760mmHg
Molecular Formula C12H11N3O2 Melting Point N/A
MSDS Chinese USA Flash Point 195.9ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of Caerulomycin A


Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases[1].

 Names

Name caerulomycin A
Synonym More Synonyms

 Caerulomycin A Biological Activity

Description Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases[1].
Related Catalog
Target

Antifungal[1] TGF-β-Smad3[1]

References

[1]. Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014 Jun 20;289(25):17515-28.

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 400.4ºC at 760mmHg
Molecular Formula C12H11N3O2
Molecular Weight 229.23500
Flash Point 195.9ºC
Exact Mass 229.08500
PSA 67.60000
LogP 1.96030
InChIKey JCTRJRHLGOKMCF-UHFFFAOYSA-N
SMILES COc1cc(C=NO)nc(-c2ccccn2)c1
Storage condition 2-8℃

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H315-H319
Precautionary Statements P301 + P310-P305 + P351 + P338
RIDADR UN 2811 6.1 / PGIII
HS Code 2933399090

 Synthetic Route

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles3

More Articles
[Development of a genetic modification system for caerulomycin producer Actinoalloteichus sp. WH1-2216-6].

Wei Sheng Wu Xue Bao 51(8) , 1032-41, (2011)

In order to enable the caerulomyicn biosynthetic study by in vivo gene disruptions, it is crucial to develop a genetic modification system for the producer Actinoalloteichus sp. WH1-2216-6.The spore g...

Total synthesis of caerulomycin C via the halogen dance reaction.

Org. Lett. 4(14) , 2385-8, (2002)

[reaction: see text] The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

Caerulomycin, an antifungal antibiotic with marked in vitro and in vivo activity against Entamoeba histolytica.

Z. Parasitenkd. 70(5) , 569-73, (1984)

The anti-amoebic action of the bipyridyl antibiotic caerulomycin was assessed in vitro and in vivo using various strains of Entamoeba histolytica from polyxenic, axenic and monoxenic cultures. Minimum...

 Caerulomycin ABioassay

View more

Name: Cytotoxicity against human KB cells after 72 hrs by MTT assay
Source: ChEMBL
Target: KB
External Id: CHEMBL1828013
Name: Cytotoxicity against human A549 cells after 24 hrs by SRB assay
Source: ChEMBL
Target: A549
External Id: CHEMBL1828012
Name: Antimicrobial activity against Pseudomonas aeruginosa after 24 hrs by agar dilution m...
Source: ChEMBL
Target: Pseudomonas aeruginosa
External Id: CHEMBL1828015
Name: Antimicrobial activity against Escherichia coli after 24 hrs by agar dilution method
Source: ChEMBL
Target: Escherichia coli
External Id: CHEMBL1828014
Name: Antimicrobial activity against Candida albicans after 24 hrs by agar dilution method
Source: ChEMBL
Target: Candida albicans
External Id: CHEMBL1828016
Name: NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell L...
Source: DTP/NCI
Target: N/A
External Id: MCF7_OneDose
Name: NCI human tumor cell line growth inhibition assay. Data for the IGROV1 Non-Small Cell...
Source: DTP/NCI
Target: N/A
External Id: IGROV1_OneDose
Name: Cytotoxicity against human K562 cells after 72 hrs by MTT assay
Source: ChEMBL
Target: K562
External Id: CHEMBL1828011
Name: Antifungal activity against fluconazole-resistant Candida krusei by CLSI protocol bas...
Source: ChEMBL
Target: Pichia kudriavzevii
External Id: CHEMBL5261018
Name: Cytotoxicity against human HL60 cells after 72 hrs by MTT assay
Source: ChEMBL
Target: HL-60
External Id: CHEMBL1828010
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 Synonyms

CERULOMYCIN
(E)-4-methoxy-2,2'-bipyridyl-6-aldoxime
CAERULOMYCIN A
4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime
4-Methoxy-[2,2']bipyridyl-6-carbaldehyd-(E)-oxim
Caerulomycin,Cerulomycin
(2,2'-Bipyridine)-6-carboxaldehyde,4-methoxy-,oxime,(E)
(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime
4-methoxy-[2,2']bipyridinyl-6-carbaldehyde oxime
4-methoxy-[2,2']bipyridyl-6-carbaldehyde-(E)-oxime
Caerulomycin A
CAERULOMYCIN
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