Caerulomycin A

Modify Date: 2025-08-25 14:25:38

Caerulomycin A Structure
Caerulomycin A structure
Common Name Caerulomycin A
CAS Number 21802-37-9 Molecular Weight 229.23500
Density 1.23g/cm3 Boiling Point 400.4ºC at 760mmHg
Molecular Formula C12H11N3O2 Melting Point N/A
MSDS Chinese USA Flash Point 195.9ºC
Symbol GHS06
GHS06
Signal Word Danger

 Use of Caerulomycin A


Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases[1].

 Names

Name caerulomycin A
Synonym More Synonyms

 Caerulomycin A Biological Activity

Description Caerulomycin A (Cerulomycin; Caerulomycin), an antifungal compound, induces generation of T cells, enhances TGF-β-Smad3 protein signaling via suppressing interferon-γ-induced STAT1 signaling. Antifungal and antibiotic activity, and used in autoimmune diseases[1].
Related Catalog
Target

Antifungal[1] TGF-β-Smad3[1]

References

[1]. Gurram RK, et al. Caerulomycin A enhances transforming growth factor-β (TGF-β)-Smad3 protein signaling by suppressing interferon-γ (IFN-γ)-signal transducer and activator of transcription 1 (STAT1) protein signaling to expand regulatory T cells (Tregs). J Biol Chem. 2014 Jun 20;289(25):17515-28.

 Chemical & Physical Properties

Density 1.23g/cm3
Boiling Point 400.4ºC at 760mmHg
Molecular Formula C12H11N3O2
Molecular Weight 229.23500
Flash Point 195.9ºC
Exact Mass 229.08500
PSA 67.60000
LogP 1.96030
Storage condition 2-8℃

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301-H315-H319
Precautionary Statements P301 + P310-P305 + P351 + P338
RIDADR UN 2811 6.1 / PGIII
HS Code 2933399090

 Synthetic Route

 Customs

HS Code 2933399090
Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles3

More Articles
[Development of a genetic modification system for caerulomycin producer Actinoalloteichus sp. WH1-2216-6].

Wei Sheng Wu Xue Bao 51(8) , 1032-41, (2011)

In order to enable the caerulomyicn biosynthetic study by in vivo gene disruptions, it is crucial to develop a genetic modification system for the producer Actinoalloteichus sp. WH1-2216-6.The spore g...

Total synthesis of caerulomycin C via the halogen dance reaction.

Org. Lett. 4(14) , 2385-8, (2002)

[reaction: see text] The total synthesis of caerulomycin C is described. Key steps in this synthesis utilize 1,2-, 1,3-, and 1,4-halogen dance reactions for the functionalization of the pyridine ring.

Caerulomycin, an antifungal antibiotic with marked in vitro and in vivo activity against Entamoeba histolytica.

Z. Parasitenkd. 70(5) , 569-73, (1984)

The anti-amoebic action of the bipyridyl antibiotic caerulomycin was assessed in vitro and in vivo using various strains of Entamoeba histolytica from polyxenic, axenic and monoxenic cultures. Minimum...

 Synonyms

CERULOMYCIN
(E)-4-methoxy-2,2'-bipyridyl-6-aldoxime
CAERULOMYCIN A
4-Methoxy-2,2'-bipyridine-6-carbaldehyde (E)-oxime
4-Methoxy-[2,2']bipyridyl-6-carbaldehyd-(E)-oxim
Caerulomycin,Cerulomycin
(2,2'-Bipyridine)-6-carboxaldehyde,4-methoxy-,oxime,(E)
(E)-4-Methoxy-[2,2'-bipyridine]-6-carbaldehyde oxime
4-methoxy-[2,2']bipyridinyl-6-carbaldehyde oxime
4-methoxy-[2,2']bipyridyl-6-carbaldehyde-(E)-oxime
Caerulomycin A
CAERULOMYCIN
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