Lycorine chloride
Lycorine chloride structure
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Common Name | Lycorine chloride | ||
|---|---|---|---|---|
| CAS Number | 2188-68-3 | Molecular Weight | 323.77 | |
| Density | N/A | Boiling Point | 477.4ºC at 760 mmHg | |
| Molecular Formula | C16H18ClNO4 | Melting Point | 210-212ºC | |
| MSDS | Chinese USA | Flash Point | 242.5ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Lycorine chlorideLycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2] |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | Lycorine hydrochloride |
|---|---|
| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2] |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Boiling Point | 477.4ºC at 760 mmHg |
|---|---|
| Melting Point | 210-212ºC |
| Molecular Formula | C16H18ClNO4 |
| Molecular Weight | 323.77 |
| Flash Point | 242.5ºC |
| PSA | 62.16000 |
| LogP | 0.68650 |
| Vapour Pressure | 6.37E-10mmHg at 25°C |
| InChIKey | VUVNTYCHKZBOMV-NVJKKXITSA-N |
| SMILES | Cl.OC1C=C2CCN3Cc4cc5c(cc4C(C1O)C23)OCO5 |
| Storage condition | 2-8°C |
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table covers safety warnings, protective measures, incompatible substances and disposal guidelines for this compound.
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic; |
| Risk Phrases | R25 |
| Safety Phrases | 45 |
| RIDADR | UN 2811 |
| Hazard Class | 6.1 |
This table lists relevant public references with title, journal and publication metadata for this compound.
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Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop.
Acta Biol. Hung. 65(4) , 396-404, (2014) Studies on Alzheimer's disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for... |
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[Study on the chemical constituents from the bulbs of Zephyranthes candida].
Zhong Yao Cai 33(11) , 1730-2, (2010) To study the chemical constituents from the bulbs of Zephyranthes candida.The chemical constituents were separated and purified by means of several chromatographies and their structures were elucidate... |
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Copper-induced synthesis of ascorbate, glutathione and phytochelatins in the marine alga Ulva compressa (Chlorophyta).
Plant Physiol. Biochem. 51 , 102-8, (2012) In order to analyze the synthesis of antioxidant and heavy metal-chelating compounds in response to copper stress, the marine alga Ulva compressa (Chlorophyta) was exposed to 10 μM copper for 7 days a... |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
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Name: Antibacterial activity against Edwardsiella ictaluri after 24 hrs
Source: ChEMBL
Target: Edwardsiella ictaluri
External Id: CHEMBL4180043
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Name: Antibacterial activity against Flavobacterium columnare ALM-00-173 after 24 hrs
Source: ChEMBL
Target: Flavobacterium columnare
External Id: CHEMBL4180044
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Name: Antibacterial activity against Flavobacterium columnare BioMed after 24 hrs
Source: ChEMBL
Target: Flavobacterium columnare
External Id: CHEMBL4180045
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Name: Antibacterial activity against Staphylococcus aureus
Source: ChEMBL
Target: Staphylococcus aureus
External Id: CHEMBL4180050
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This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| Lycorine hydrochloride |
| Lycorinehydrochloride |
| Licorin hydrochloride |
| galanthidine,hydrochloride |
| (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1) |
| 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-, hydrochloride (1:1) |
| Lycorinechloride |
| Lycorine (hydrochloride) |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the InChIKey of Lycorine hydrochloride? |
| A: InChIKey of Lycorine hydrochloride is VUVNTYCHKZBOMV-NVJKKXITSA-N. |
| Q: What is the safety information for Lycorine hydrochloride? |
| A: Safety information for Lycorine hydrochloride: 45. |
| Q: What is the polar surface area (PSA) of Lycorine hydrochloride? |
| A: Polar surface area (PSA) of Lycorine hydrochloride is 62.16000. |
| Q: What is the LogP of Lycorine hydrochloride? |
| A: LogP of Lycorine hydrochloride is 0.68650. |
| Q: What English synonyms does Lycorine hydrochloride have? |
| A: English synonyms of Lycorine hydrochloride: Lycorine hydrochloride, Lycorinehydrochloride, Licorin hydrochloride, galanthidine,hydrochloride, (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1), 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-, hydrochloride (1:1), Lycorinechloride, Lycorine (hydrochloride). |
| Q: What is the boiling point of Lycorine hydrochloride? |
| A: Boiling point of Lycorine hydrochloride is 477.4ºC at 760 mmHg. |
| Q: What is the molecular formula of Lycorine hydrochloride? |
| A: Molecular formula of Lycorine hydrochloride is C16H18ClNO4. |
| Q: What is the English name of Lycorine hydrochloride? |
| A: The English name of Lycorine hydrochloride is Lycorine hydrochloride. |
| Q: What are the storage conditions for Lycorine hydrochloride? |
| A: Storage conditions for Lycorine hydrochloride: 2-8°C. |
| Q: What is the CAS number of Lycorine hydrochloride? |
| A: CAS number of Lycorine hydrochloride is 2188-68-3. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |