Lycorine chloride

Modify Date: 2025-08-20 20:55:27

Lycorine chloride Structure
Lycorine chloride structure
 Common Name Lycorine chloride
CAS Number 2188-68-3 Molecular Weight 323.77
Density N/A Boiling Point 477.4ºC at 760 mmHg
Molecular Formula C16H18ClNO4 Melting Point 210-212ºC
MSDS Chinese USA Flash Point 242.5ºC
Symbol GHS06
GHS06		 Signal Word Danger

 Use of Lycorine chloride


Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2]

 Names

Name Lycorine hydrochloride
Synonym More Synonyms

 Lycorine chloride Biological Activity

Description Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2]
Related Catalog
References

[1]. Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012).

[2]. Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013).

 Chemical & Physical Properties

Boiling Point 477.4ºC at 760 mmHg
Melting Point 210-212ºC
Molecular Formula C16H18ClNO4
Molecular Weight 323.77
Flash Point 242.5ºC
PSA 62.16000
LogP 0.68650
Vapour Pressure 6.37E-10mmHg at 25°C
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OL2910000
CHEMICAL NAME :
Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-, hydrochloride
CAS REGISTRY NUMBER :
2188-68-3
LAST UPDATED :
198803
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C16-H17-N-O4.Cl-H
MOLECULAR WEIGHT :
323.80

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
230 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
117 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
123 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 54,21,1958

 Safety Information

Symbol GHS06
GHS06
Signal Word Danger
Hazard Statements H301
Precautionary Statements P301 + P310
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Hazard Codes T: Toxic;
Risk Phrases R25
Safety Phrases 45
RIDADR UN 2811
Hazard Class 6.1

 Articles26

More Articles
Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop.

Acta Biol. Hung. 65(4) , 396-404, (2014)

Studies on Alzheimer's disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for...

[Study on the chemical constituents from the bulbs of Zephyranthes candida].

Zhong Yao Cai 33(11) , 1730-2, (2010)

To study the chemical constituents from the bulbs of Zephyranthes candida.The chemical constituents were separated and purified by means of several chromatographies and their structures were elucidate...

Copper-induced synthesis of ascorbate, glutathione and phytochelatins in the marine alga Ulva compressa (Chlorophyta).

Plant Physiol. Biochem. 51 , 102-8, (2012)

In order to analyze the synthesis of antioxidant and heavy metal-chelating compounds in response to copper stress, the marine alga Ulva compressa (Chlorophyta) was exposed to 10 μM copper for 7 days a...

 Synonyms

Lycorine hydrochloride
Lycorinehydrochloride
Licorin hydrochloride
galanthidine,hydrochloride
(1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1)
1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-, hydrochloride (1:1)
Lycorinechloride
Lycorine (hydrochloride)
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.
Top Suppliers:I want be here

Get all suppliers and price by the below link:

Lycorine chloride suppliers

Price: $66/10mM*1mLinDMSO

Reference only. check more Lycorine chloride price

Related Compounds: More...
(-)-Lycorine
476-28-8
Benzoyl chloride, 2-(4-morpholinyl)-5-nitro
847971-78-2
Sebacoyl chloride
111-19-3
Benzoyl chloride, 4-[(acetyloxy)methyl]- (9CI)
78616-33-8
Benzeneethanesulfenyl chloride, alpha-chloro-beta-oxo- (9CI)
58861-72-6
Oxiranecarbonyl chloride, 2-methyl-3-phenyl-, trans- (9CI)
89848-84-0
Ethanesulfonyl chloride
594-44-5
YTTRIUM CHLORIDE HEXAHYDRATE
10025-94-2
Cyclohexanesulfenyl chloride
17797-03-4
6-(3-Methoxyphenyl)-3-oxo-2,3-dihydropyridazine-4-carboxylic acid
1481674-93-4
Benzyl 2-methyl-2-(1-methylcyclopropyl)propanoate
1447944-33-3
1-(6-Chloro-pyridazin-3-yl)-cyclopropanecarbonitrile
1352753-98-0
Ethyl 1-(6-chloropyridazin-3-yl)cyclopropane-1-carboxylate
1352754-02-9
3-(Azetidin-1-yl)-6-chloropyridazine
1352754-17-6
2-Chloro-4-(diethylamino)pyridine-3-carbonitrile
903570-81-0
8-(4-Methylpiperazin-1-yl)tetrazolo[1,5-a]pyrazine
1427176-25-7
5-Bromo-8-(4-methylpiperazin-1-yl)tetrazolo[1,5-a]pyrazine
1427176-27-9
Tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate
1189550-72-8
tert-Butyl-3-((6-chloropyridin-3-yl)oxy)pyrrolidine-1-carboxylate
1379533-06-8
Chemsrc provides Lycorine chloride(CAS#:2188-68-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Lycorine chloride are included as well.>> amp version: Lycorine chloride

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved