Lycorine chloride
Modify Date: 2024-01-02 17:37:27
Lycorine chloride structure
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Common Name | Lycorine chloride | ||
|---|---|---|---|---|
| CAS Number | 2188-68-3 | Molecular Weight | 323.77 | |
| Density | N/A | Boiling Point | 477.4ºC at 760 mmHg | |
| Molecular Formula | C16H18ClNO4 | Melting Point | 210-212ºC | |
| MSDS | Chinese USA | Flash Point | 242.5ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of Lycorine chlorideLycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2] |
| Name | Lycorine hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Lycorine (hydrochloride) is VE-cadherin inhibitor,and has IC50 of 1.2μM in Hey1B cell.IC50: 1.2μM (Hey1B cell)[2]In vitro:Lycorine (hydrochloride) executed an anti-melanoma vasculogenic effect by inhibiting VE-cadherin gene expression in C8161 cells and caused a decrease in cell surface exposure of VE-cadherin protein. Consistently, LH significantly suppressed VE-cadherin gene promoter activity. [1]Lycorine (hydrochloride) effectively inhibited mitotic proliferation of Hey1B cells (half maximal inhibitory concentration = 1.2 μM) with very low toxicity, resulting in cell cycle arrest at the G2/M transition through enhanced expression of the cell cycle inhibitor p21 and marked down-regulation of cyclin D3 expression. Moreover, LH suppressed both the formation of capillary-like tubes by Hey1B cells cultured in vitro.[2]In vivo: Lycorine effectively suppressed C8161 cell-dominant tumor formation and generation of tumor blood vessels in vivo with low toxicity.[1]Lycorine (hydrochloride) suppressed the formation of the ovarian cancer cell-dominant neovascularization in vivo when administered to Hey1B-xenotransplanted mice, suggest that LH selectively inhibits ovarian cancer cell proliferation and neovascularization and is a potential drug candidate for anti-ovarian cancer therapy.[2] |
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| Related Catalog | |
| References |
| Boiling Point | 477.4ºC at 760 mmHg |
|---|---|
| Melting Point | 210-212ºC |
| Molecular Formula | C16H18ClNO4 |
| Molecular Weight | 323.77 |
| Flash Point | 242.5ºC |
| PSA | 62.16000 |
| LogP | 0.68650 |
| Vapour Pressure | 6.37E-10mmHg at 25°C |
| Storage condition | 2-8°C |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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Comparison of anti-acetylcholinesterase activity of bulb and leaf extracts of Sternbergia candida Mathew & T. Baytop.
Acta Biol. Hung. 65(4) , 396-404, (2014) Studies on Alzheimer's disease have been highlighted due to increasing prevalence of this disease. Oldest hypothesis about the pathophysiology strengthens the research of cholinesterase inhibitors for... |
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[Study on the chemical constituents from the bulbs of Zephyranthes candida].
Zhong Yao Cai 33(11) , 1730-2, (2010) To study the chemical constituents from the bulbs of Zephyranthes candida.The chemical constituents were separated and purified by means of several chromatographies and their structures were elucidate... |
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Copper-induced synthesis of ascorbate, glutathione and phytochelatins in the marine alga Ulva compressa (Chlorophyta).
Plant Physiol. Biochem. 51 , 102-8, (2012) In order to analyze the synthesis of antioxidant and heavy metal-chelating compounds in response to copper stress, the marine alga Ulva compressa (Chlorophyta) was exposed to 10 μM copper for 7 days a... |
| Lycorine hydrochloride |
| Lycorinehydrochloride |
| Licorin hydrochloride |
| galanthidine,hydrochloride |
| (1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol hydrochloride (1:1) |
| 1H-[1,3]Dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol, 2,4,5,7,12b,12c-hexahydro-, (1S,2S,12bS,12cS)-, hydrochloride (1:1) |
| Lycorinechloride |
| Lycorine (hydrochloride) |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Lycorine chloride
- Price: ￥98.0/20mg ￥728.0/5g ￥218.0/1g
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Lycorine hydrochloride
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: Lycorine hydrochloride
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Lycorine hydrochloride
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
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Price: $66/10mM*1mLinDMSO
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