(-)-Lycorine

Modify Date: 2025-08-20 11:29:47

(-)-Lycorine structure	Common Name	(-)-Lycorine
	CAS Number	476-28-8	Molecular Weight	287.310
	Density	1.5±0.1 g/cm3	Boiling Point	477.4±45.0 °C at 760 mmHg
	Molecular Formula	C₁₆H₁₇NO₄	Melting Point	253-255ºC (dec.)
	MSDS	N/A	Flash Point	242.5±28.7 °C

Use of (-)-Lycorine

Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant family with antiviral, antimalarial and antiinflammation activities. Lycorine inhibits the growth and metastasis of hormone-refractory anti-prostate cancer (PCa) and induces cell apoptosis[1].

Name	lycorine
Synonym	More Synonyms

Description	Lycorine is a natural alkaloid extracted from the Amaryllidaceae plant family with antiviral, antimalarial and antiinflammation activities. Lycorine inhibits the growth and metastasis of hormone-refractory anti-prostate cancer (PCa) and induces cell apoptosis[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Lycorine inhibits cell proliferation in a dose-dependent manner in the abovementioned 4 PCa cell lines, and the IC50 ranged from 5 μM to 10 μM., it also shows Lycorine has little effects on PNT1A cell's proliferation[1].
References	[1]. Hu M, et al.Lycorine is a novel inhibitor of the growth and metastasis of hormone-refractory prostate cancer.Oncotarget. 2015 Jun 20;6(17):15348-61.

Density	1.5±0.1 g/cm3
Boiling Point	477.4±45.0 °C at 760 mmHg
Melting Point	253-255ºC (dec.)
Molecular Formula	C₁₆H₁₇NO₄
Molecular Weight	287.310
Flash Point	242.5±28.7 °C
Exact Mass	287.115753
PSA	62.16000
LogP	0.77
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.733
InChIKey	XGVJWXAYKUHDOO-DANNLKNASA-N
SMILES	OC1C=C2CCN3Cc4cc5c(cc4C(C1O)C23)OCO5

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OL2900000

CHEMICAL NAME :: Lycoran-1-alpha,2-beta-diol, 3,3-alpha-didehydro-

CAS REGISTRY NUMBER :: 476-28-8

LAST UPDATED :: 199709

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C16-H17-N-O4

MOLECULAR WEIGHT :: 287.34

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 10700 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),23S,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 145 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - rigidity (including catalepsy) Lungs, Thorax, or Respiration - other changes

REFERENCE :: NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 56(1),23S,1960

Hazard Codes	T: Toxic;
Risk Phrases	R25
Safety Phrases	45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Hazard Class	9.0

Precursor 8
CAS#:69787-57-1 1-acetyl-2-chlo... CAS#:2492-05-9 1,2-Diacetoxyly... CAS#:6391-78-2 (1S,2S,3a(1)S,1... CAS#:7344-73-2 1-Acetoxylycorine
CAS#:58700-92-8 1α-hydroxy-9,10... CAS#:58700-89-3 α-dihydrolycori... CAS#:58700-93-9 (1S,2S,3a(1)S,1... CAS#:71635-31-9 9,10-methanediy...
DownStream 3
CAS#:40360-71-2 Anhydrolycorinone CAS#:641-89-4 anhydrolycorine CAS#:40141-98-8 5-methyl-[1,3]d...

Name: Antiviral activity against Poliovirus infected african green monkey Vero cells assess...
Source: ChEMBL
Target: Enterovirus C
External Id: CHEMBL1024109

Name: Antiviral activity against Poliovirus infected african green monkey Vero cells assess...
Source: ChEMBL
Target: Enterovirus C
External Id: CHEMBL1024108

Name: Antiviral activity against Semliki forest virus infected african green monkey Vero ce...
Source: ChEMBL
Target: Semliki Forest virus
External Id: CHEMBL1024105

Name: Selectivity ratio of CC50 for Rhesus macaque LLC-MK2 cells to EC50 for HCoV-NL63 infe...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4723155

Name: Selectivity ratio of CC50 for HAE cells to EC50 for SARS-CoV BJ-001 infected in Afric...
Source: ChEMBL
Target: N/A
External Id: CHEMBL4723152

Name: Inhibition of LPS-induced NO production in ddY mouse macrophages at 3 uM after 20 hrs...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL1003486

Name: Cytotoxicity against mouse ddY macrophages assessed as cell viability at 3 um after 7...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1003487

Name: Inhibition of LPS-induced NO production in ddY mouse macrophages at 1 uM after 20 hrs...
Source: ChEMBL
Target: Macrophage
External Id: CHEMBL1003484

Name: Cytotoxicity against mouse ddY macrophages assessed as cell viability at 1 um after 7...
Source: ChEMBL
Target: N/A
External Id: CHEMBL1003485

Name: Antiviral activity against HCoV-OC43 infected in BALB/c mouse assessed as protection ...
Source: ChEMBL
Target: Human coronavirus OC43
External Id: CHEMBL4723193

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3,3a-Didehydrolycoran-1a,2b-diol

Amarylline

(1a,2b)-3,12-Didehydro-9,10-[methylenebis(oxy)]galanthan-1,2-diol

(1S,2S,12bS,12cS)-2,4,5,7,12b,12c-Hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine-1,2-diol

Lycorine

(1S,2S,12bS,12cS)-1,2-diol-2,4,5,7,12b,12c-hexahydro-1H-[1,3]dioxolo[4,5-j]pyrrolo[3,2,1-de]phenanthridine

Galanthidine

Belamarine

Licorine

Narcissine

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (-)-Lycorine
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China
Product Name: (-)-Lycorine
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China
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naturewill
China
Product Name: (-)-Lycorine
Price: ￥Inquiry/5mg ￥Inquiry/20mg ￥Inquiry/100mg ￥Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
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(-)-Lycorine

Use of (-)-Lycorine

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(-)-Lycorine Biological Activity

Chemical & Physical Properties

Toxicological Information

CHEMICAL IDENTIFICATION

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

Safety Information

Synthetic Route

Precursor & DownStream

(-)-LycorineBioassay

Synonyms

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