4',7-Dihydroxyflavone

Modify Date: 2025-08-23 12:40:46

4',7-Dihydroxyflavone structure	Common Name	4',7-Dihydroxyflavone
	CAS Number	2196-14-7	Molecular Weight	254.238
	Density	1.4±0.1 g/cm3	Boiling Point	512.8±50.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₀O₄	Melting Point	324-325ºC
	MSDS	N/A	Flash Point	201.2±23.6 °C

Use of 4',7-Dihydroxyflavone

7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].

Name	4',7-dihydroxyflavone
Synonym	More Synonyms

Description	7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2.7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 µM[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> CCR Signaling Pathways >> Immunology/Inflammation >> CCR Research Areas >> Inflammation/Immunology
Target	IC50: 1.4 μM (NCI-H292 human airway epithelial cell) (7,4'-Dihydroxyflavone)[2]
References	[1]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Prevents Dexamethasone Paradoxical Adverse Effect on Eotaxin Production by Human Fibroblasts. Phytother Res. 2017 Mar;31(3):449-458. [2]. Liu C, et al. The Flavonoid 7,4'-Dihydroxyflavone Inhibits MUC5AC Gene Expression, Production, and Secretion via Regulation of NF-κB, STAT6, and HDAC2. Phytother Res. 2015 Jun;29(6):925-32.

Density	1.4±0.1 g/cm3
Boiling Point	512.8±50.0 °C at 760 mmHg
Melting Point	324-325ºC
Molecular Formula	C₁₅H₁₀O₄
Molecular Weight	254.238
Flash Point	201.2±23.6 °C
Exact Mass	254.057907
PSA	70.67000
LogP	2.54
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.699
InChIKey	LCAWNFIFMLXZPQ-UHFFFAOYSA-N
SMILES	O=c1cc(-c2ccc(O)cc2)oc2cc(O)ccc12

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LK8329000

CHEMICAL NAME :: Flavone, 4',7-dihydroxy-

CAS REGISTRY NUMBER :: 2196-14-7

BEILSTEIN REFERENCE NO. :: 0224356

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H10-O4

MOLECULAR WEIGHT :: 254.25

WISWESSER LINE NOTATION :: T66 BO EVJ CR DQ& IQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 ug/plate

REFERENCE :: ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 3,401,1981

Hazard Codes	Xi
HS Code	2914501900

HS Code	2914501900
Summary	2914501900 other ketone-phenols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

7,4'-Dihydroxyflavanone

4H-1-Benzopyran-4-one, 7-hydroxy-2-(4-hydroxyphenyl)-

7,4'-Dihydroxyflavone

FLAVONE,4',7-DIHYDROXY

7-Hydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one

7-hydroxy-2-(4-hydroxyphenyl)chromen-4-one

4',7-Dihydroxyflavone

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 4',7-Dihydroxyflavone
Price: Check
Purity: 98.0%
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Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: 4',7-Dihydroxyflavone
Price: ￥2458.0/5mg
Purity: 98.0%
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DC Chemicals Limited
China
Product Name: 4',7-Dihydroxyflavone
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
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Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 7-HYDROXY-2-(4-HYDROXYPHENYL)-4H-CHROMEN-4-ONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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4',7-Dihydroxyflavone

Use of 4',7-Dihydroxyflavone

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