Potassium oxonate
Potassium oxonate structure
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Common Name | Potassium oxonate | ||
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| CAS Number | 2207-75-2 | Molecular Weight | 195.175 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C4H2KN3O4 | Melting Point | 300 °C(lit.) | |
| MSDS | N/A | Flash Point | N/A | |
Use of Potassium oxonateOxonic acid potassium salt is an inhibitor of uricase, oxonic inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.IC50 value: Target: On p.o. administration of 5-FU (2 mg/kg) and a potent inhibitor of 5-FU degradation to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) was found to inhibit the formation of 5-fluorouridine-5'-monophosphate from 5-FU and its subsequent incorporation into the RNA fractions of small and large intestine but not of tumor and bone marrow tissues [1]. Oxonic acid diet increased plasma uric acid by 80-90 micromol/l, while blood pressure was elevated only in hyperuricemic 5/6 nephrectomy rats (18 mmHg) [2]. |
This table lists Chinese names, IUPAC names and various aliases of this chemical substance.
| Name | potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate |
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| Synonym | More Synonyms |
This table contains bioactivity, target information and biological‑assay experimental data of this compound.
| Description | Oxonic acid potassium salt is an inhibitor of uricase, oxonic inhibits the phosphorylation of 5-FU to 5-fluorouridine-5'-monophosphate catalyzed by pyrimidine phosphoribosyl-transferase in a different manner from allopurinol in cell-free extracts and intact cells in vitro.IC50 value: Target: On p.o. administration of 5-FU (2 mg/kg) and a potent inhibitor of 5-FU degradation to Yoshida sarcoma-bearing rats, oxonic acid (10 mg/kg) was found to inhibit the formation of 5-fluorouridine-5'-monophosphate from 5-FU and its subsequent incorporation into the RNA fractions of small and large intestine but not of tumor and bone marrow tissues [1]. Oxonic acid diet increased plasma uric acid by 80-90 micromol/l, while blood pressure was elevated only in hyperuricemic 5/6 nephrectomy rats (18 mmHg) [2]. |
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| Related Catalog | |
| References |
This table shows physicochemical parameters including melting point, boiling point, density, solubility and optical rotation. Missing data is marked as N/A.
| Melting Point | 300 °C(lit.) |
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| Molecular Formula | C4H2KN3O4 |
| Molecular Weight | 195.175 |
| Exact Mass | 194.968231 |
| PSA | 118.74000 |
| InChIKey | IAPCTXZQXAVYNG-UHFFFAOYSA-M |
| SMILES | O=C([O-])c1nc(=O)[nH]c(=O)[nH]1.[K+] |
| Storage condition | Refrigerator, Under Inert Atmosphere |
This table provides MSDS information including hazard classification, first‑aid, fire‑fighting, spill handling, operation and storage instructions.
This table summarizes toxicological test data, acute & chronic toxicity and ecological hazard parameters for this chemical.
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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This table presents publicly reported synthetic routes, reaction conditions, reactants and product information of the compound.
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~80%
Potassium oxonate CAS#:2207-75-2 |
| Literature: Poje, M.; Sokolic-Maravic, Lea Tetrahedron, 1986 , vol. 42, # 2 p. 747 - 752 |
This table lists upstream starting materials and downstream derivative products related to this chemical.
| Precursor 1 | |
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| DownStream 0 | |
This table shows customs‑related data including HS‑code, tariff and regulatory conditions for import and export.
| HS Code | 2933699090 |
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| Summary | 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0% |
This table contains target information, in‑vitro & in‑vivo assay data for this compound.
This table collects all English aliases, systematic names and CAS‑related synonyms of the compound.
| 1,3,5-Triazine-2-carboxylic acid, 1,4,5,6-tetrahydro-4,6-dioxo-, potassium salt (1:1) |
| Allantoxanic acid |
| monopotassium 1,2,3,4-tetrahydro-2,4-dioxo-1,3,5-triazine-6-carboxylate |
| Potassium Oxonate |
| Oxonic acid potassium salt |
| Oxonic acid |
| Potassium 4,6-Dihydroxy-1,3,5-triazine-2-carboxylate |
| Potassium azaorotate |
| Oxonate |
| MFCD00010565 |
| Potassium Allantoxanate |
| 5-Aza-orotsaeure K-Salz |
| potassium 1,4,5,6-tetrahydro-4,6-dioxo-1,3,5-triazine-2-carboxylate |
| Potassium 4,6-dioxo-1,4,5,6-tetrahydro-1,3,5-triazine-2-carboxylate |
| Allantoxanic Acid Potassium Salt |
| Oxonic acid,potassium salt |
| Oteracil potassium |
| Oxonate,potassium |
| EINECS 218-627-5 |
This section contains frequently‑asked‑questions about this compound, including basic parameters, properties, storage conditions and corresponding answers.
| Q: What is the molecular weight of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Molecular weight of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is 195.175. |
| Q: What are the storage conditions for potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Storage conditions for potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate: Refrigerator, Under Inert Atmosphere. |
| Q: What is the English name of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: The English name of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate. |
| Q: What is the InChIKey of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: InChIKey of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is IAPCTXZQXAVYNG-UHFFFAOYSA-M. |
| Q: What is the safety information for potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Safety information for potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate: S24/25. |
| Q: What is the melting point of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Melting point of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is 300 °C(lit.). |
| Q: What is the molecular formula of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Molecular formula of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is C4H2KN3O4. |
| Q: What is the polar surface area (PSA) of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Polar surface area (PSA) of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is 118.74000. |
| Q: What are the upstream materials of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: Related upstream materials(CAS) of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate: 105245-87-2. |
| Q: What is the SMILES notation of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate? |
| A: SMILES notation of potassium,4,6-dioxo-1H-1,3,5-triazine-2-carboxylate is O=C([O-])c1nc(=O)[nH]c(=O)[nH]1.[K+]. |
This table lists manufacturers and suppliers of this compound, including vendor names and product supply reference information.
| Shanghai Nianxing Industrial Co., Ltd |
| Dayang Chem (Hangzhou) Co., Ltd. |
| Henan Tianfu Chemical Co., Ltd. |