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1227193-98-7

1227193-98-7 structure
1227193-98-7 structure
  • Name: 2-Methylthio-AMP diTEA
  • Chemical Name: 2-Methylthio-AMP diTEA
  • CAS Number: 1227193-98-7
  • Molecular Formula: C23H46N7O7PS
  • Molecular Weight: 595.69
  • Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
  • Create Date: 2022-01-06 22:57:08
  • Modify Date: 2024-01-27 13:25:20
  • 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
Name 2-Methylthio-AMP diTEA
Description 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
Related Catalog
Target

P2Y12[1]

In Vitro 2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].
References

[1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43.

[2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42.

[3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.
Molecular Formula C23H46N7O7PS
Molecular Weight 595.69
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title: CAS No. 1227193-98-7 | Chemsrc address: https://m.chemsrc.com/en/baike/1687059.html

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