Shanghai Nianxing Industrial Co., Ltd
China
Product Name: 2-Methylthio-AMP diTEA
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: 2-Methylthio-AMP diTEA
Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1227193-98-7

1227193-98-7 structure

1227193-98-7 structure

Name: 2-Methylthio-AMP diTEA
Chemical Name: 2-Methylthio-AMP diTEA
CAS Number: 1227193-98-7
Molecular Formula: C₂₃H₄₆N₇O₇PS
Molecular Weight: 595.69
Catalog: Signaling Pathways GPCR/G Protein P2Y Receptor
Create Date: 2022-01-06 22:57:08
Modify Date: 2025-08-27 19:10:33
2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].

Name	2-Methylthio-AMP diTEA

Description	2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> P2Y Receptor
Target	P2Y12[1]
In Vitro	2-Methylthio-AMP (2-MeSAMP) diTEA inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) diTEA does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP diTEA fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1].
References	[1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.

Molecular Formula	C₂₃H₄₆N₇O₇PS
Molecular Weight	595.69

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.