MI 219
Modify Date: 2024-02-04 18:27:05
MI 219 structure
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Common Name | MI 219 | ||
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| CAS Number | 908027-55-4 | Molecular Weight | 552.465 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 779.9±60.0 °C at 760 mmHg | |
| Molecular Formula | C27H32Cl2FN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 425.5±32.9 °C | |
Use of MI 219MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX; disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells; inhibits tumor growth in mouse xenograft models. |
| Name | (2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide |
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| Synonym | More Synonyms |
| Description | MI 219 is a potent, specific MDM2-p53 inhibitor with Ki of 5 nM, >10,000-fold selective for MDM2 over MDMX; disrupts the MDM2-p53 interaction and activates the p53 pathway in cells with wild-type p53, which leads to induction of cell cycle arrest in all cells and selective apoptosis in tumor cells; inhibits tumor growth in mouse xenograft models. |
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| References | References 1. Shangary S, et al. Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3933-8. 2. Peterson LF, et al. Leukemia. 2011 May;25(5):761-9. 3. Feng FY, et al. Neoplasia. 2016 Apr;18(4):213-22. View Related Products by Target MDM2-p53 |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 779.9±60.0 °C at 760 mmHg |
| Molecular Formula | C27H32Cl2FN3O4 |
| Molecular Weight | 552.465 |
| Flash Point | 425.5±32.9 °C |
| Exact Mass | 551.175415 |
| LogP | 4.48 |
| Vapour Pressure | 0.0±2.8 mmHg at 25°C |
| Index of Refraction | 1.629 |
| Spiro[3H-indole-3,3'-pyrrolidine]-5'-carboxamide, 6-chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-1,2-dihydro-2-oxo-, (2'R,3S,4'R,5'R)- |
| (2'R,3S,4'R,5'R)-6-Chloro-4'-(3-chlorophenyl)-N-[(3S)-3,4-dihydroxybutyl]-2'-(2,2-dimethylpropyl)-5-fluoro-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide |