SOS1 activator 17
Modify Date: 2025-10-07 13:51:28
SOS1 activator 17 structure
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Common Name | SOS1 activator 17 | ||
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| CAS Number | 2228955-02-8 | Molecular Weight | 496.436 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H27Cl2N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SOS1 activator 17SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels. |
| Name | SOS1 activator 17 |
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| Description | SOS1 activator 17 is a small molecule activator of guanine nucleotide exchange factor SOS1 with EC50 of 0.8 uM, modulates RAS signaling in vitro; activates the nucleotide exchange process at submicromolar concentrations in vitro, increases levels of active RAS-GTP in HeLa cells, and elicits signaling changes in the MAPK-ERK pathway, resulting in a decrease in pERK1/2T202/Y204 protein levels. |
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| References | References 1. Abbott JR, et al. J Med Chem. 2018 Jul 11. doi: 10.1021/acs.jmedchem.8b00360. View Related Products by Target Ras |
| Molecular Formula | C26H27Cl2N5O |
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| Molecular Weight | 496.436 |
| InChIKey | VSYAAFJHDSVRBY-KXXGJQBSSA-N |
| SMILES | NC(Cc1c[nH]c2cc(Cl)ccc12)C(=O)N1CC2CN(Cc3c[nH]c4ccc(Cl)cc34)CC2C1 |