BMT-090605 hydrochloride
Modify Date: 2024-07-15 18:06:30
BMT-090605 hydrochloride structure
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Common Name | BMT-090605 hydrochloride | ||
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| CAS Number | 2231664-45-0 | Molecular Weight | 400.90 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H25ClN4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of BMT-090605 hydrochlorideBMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1]. |
| Name | BMT-090605 hydrochloride |
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| Description | BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1]. |
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| Related Catalog | |
| Target |
IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1] |
| In Vitro | BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1]. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1]. |
| In Vivo | BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1] Dosage: 0.3-3 µg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia. |
| Molecular Formula | C21H25ClN4O2 |
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| Molecular Weight | 400.90 |