2231664-45-0
2231664-45-0 structure
- Name: BMT-090605 hydrochloride
- Chemical Name: BMT-090605 hydrochloride
- CAS Number: 2231664-45-0
- Molecular Formula: C21H25ClN4O2
- Molecular Weight: 400.90
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-11-21 18:41:11
- Modify Date: 2024-07-15 18:06:30
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BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1].
| Name | BMT-090605 hydrochloride |
|---|
| Description | BMT-090605 hydrochloride is a potent, selective the adapter protein-2 associated kinase 1 (AAK1) inhibitor with an IC50 value of 0.6 nM. BMT-090605 hydrochloride shows antinociceptive activity. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively. BMT-090605 hydrochloride can be used for the research of neuropathic pain[1]. |
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| Related Catalog | |
| Target |
IC50: 0.6 nM (AAK1); 45 nM (BIKE); 60 nM (GAK)[1] |
| In Vitro | BMT-090605 hydrochloride shows AAK1inhibitory activity with an IC50 of 0.63 nM[1]. BMT-090605 hydrochloride inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50 values of 45 nM and 60 nM, respectively[1]. |
| In Vivo | BMT-090605 hydrochloride(intrathecal; 0.3-3 µg/rat) causes antinociception by inhibiting AAK1 in the spinal cord[1]. Animal Model: Male Sprague-Dawley rats (chronic constriction injury (CCI) model)[1] Dosage: 0.3-3 µg/rat Administration: Intrathecal Result: Caused a dose-dependent reduction in thermal hyperalgesia. |
| Molecular Formula | C21H25ClN4O2 |
|---|---|
| Molecular Weight | 400.90 |