DMA-135 hydrochloride

Modify Date: 2024-04-03 19:42:22

DMA-135 hydrochloride Structure
DMA-135 hydrochloride structure
Common Name DMA-135 hydrochloride
CAS Number 2237925-62-9 Molecular Weight 359.81
Density N/A Boiling Point N/A
Molecular Formula C16H18ClN7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DMA-135 hydrochloride


DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].

 Names

Name DMA-135 hydrochloride

 DMA-135 hydrochloride Biological Activity

Description DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication. DMA-135 hydrochloride binds to enterovirus 71 (EV71) SLII domain with moderately high affinity (KD= 520 nM). DMA-135 hydrochloride has no significant toxicity in cell-based studies[1].
Related Catalog
References

[1]. Davila-Calderon J, Patwardhan NN, Chiu LY, et al. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun. 2020;11(1):4775. Published 2020 Sep 22.

 Chemical & Physical Properties

Molecular Formula C16H18ClN7O
Molecular Weight 359.81