2237925-61-8
2237925-61-8 structure
- Name: DMA-135 freebase
- Chemical Name: DMA-135 freebase
- CAS Number: 2237925-61-8
- Molecular Formula: C16H17N7O
- Molecular Weight: 323.360
- Create Date: 2022-07-29 10:54:42
- Modify Date: 2024-02-04 10:30:54
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DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.DMA-135 changes the local and global structure of the EV71 SLII IRES domain.DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex.
| Name | DMA-135 freebase |
|---|
| Description | DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.DMA-135 changes the local and global structure of the EV71 SLII IRES domain.DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex. |
|---|---|
| References | 1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775. |
| Molecular Formula | C16H17N7O |
|---|---|
| Molecular Weight | 323.360 |