DMA-135 freebase
Modify Date: 2024-02-04 10:30:54
DMA-135 freebase structure
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Common Name | DMA-135 freebase | ||
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| CAS Number | 2237925-61-8 | Molecular Weight | 323.360 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17N7O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of DMA-135 freebaseDMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.DMA-135 changes the local and global structure of the EV71 SLII IRES domain.DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex. |
| Name | DMA-135 freebase |
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| Description | DMA-135 (DMA135) is a RNA-biased small molecule binds to the EV71 SLII IRES domain (Kd=520 nM), dose-dependently (IC50=7.54 uM) inhibits EV-71 viral translation and replication.DMA-135 inhibits EV71 replication by attenuating IRES-dependent translation at dosages of relatively low cellular toxicity.DMA-135 changes the local and global structure of the EV71 SLII IRES domain.DMA-135 allosterically stabilizes a AUF1 (cellular protein)-SLII-(DMA-135) ternary complex. |
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| References | 1. Jesse Davila-Calderon, et al. Nat Commun. 2020 Sep 22;11(1):4775. |
| Molecular Formula | C16H17N7O |
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| Molecular Weight | 323.360 |