Oleoyl-D-lysine

Modify Date: 2024-01-10 16:19:34

Oleoyl-D-lysine Structure
Oleoyl-D-lysine structure
Common Name Oleoyl-D-lysine
CAS Number 2240164-55-8 Molecular Weight 410.63
Density N/A Boiling Point N/A
Molecular Formula C24H46N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Oleoyl-D-lysine


Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression[1].

 Names

Name Oleoyl-D-lysine

 Oleoyl-D-lysine Biological Activity

Description Oleoyl-D-lysine is a selective Glycine Transporter-2 (GlyT2) inhibitor based on lipid. Oleoyl-D-lysine reverses neuropathic pain in mice, shows antidrowsiness effect on chronic neuropathic pain. Oleoyl-D-lysine is safe and effective without respiratory depression[1].
Related Catalog
Target

Glycine Transporter-2 (GlyT2)[1]

In Vivo Oleoyl-D-lysine effectively reverses neuropathic pain in a mouse model of chronic neuropathic (chronic constriction injury) pain, reaching a peak analgesic dose of 30 mg/kg without causing respiratory depression; resultig mild side effects at 100 mg/kg without causing convulsions[1].
References

[1]. Wilson BS, et al. Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-D-Lysine, Reverses Chronic Neuropathic Pain but Not Acute or Inflammatory Pain in Male Mice. J Pharmacol Exp Ther. 2022 Sep;382(3):246-255.  

 Chemical & Physical Properties

Molecular Formula C24H46N2O3
Molecular Weight 410.63
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