Retapamulin

Modify Date: 2024-01-03 11:30:14

Retapamulin Structure
Retapamulin structure
 Common Name Retapamulin
CAS Number 224452-66-8 Molecular Weight 517.763
Density 1.2±0.1 g/cm3 Boiling Point 594.9±50.0 °C at 760 mmHg
Molecular Formula C30H47NO4S Melting Point N/A
MSDS N/A Flash Point 313.6±30.1 °C

 Use of Retapamulin


Retapamulin(SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.IC50 Value: 3 nM(Kd, E.coli)Target: AntibacterialRetapamulin is a topical antibiotic developed by GlaxoSmithKline. Retapamulin(SB-275833) is the first drug in the new class of pleuromutilin antibiotics to be approved for human use.Retapamulin(SB-275833) is marketed as an ointment under the brand names Altabax and Altargo. Retapamulin(SB-275833) is useful for Antibiotics.

 Names

Name Retapamulin
Synonym More Synonyms

 Retapamulin Biological Activity

Description Retapamulin(SB-275833) is a topical antibiotic, which binds to both E. coli and S. aureus ribosomes with similar potencies with Kd of 3 nM.IC50 Value: 3 nM(Kd, E.coli)Target: AntibacterialRetapamulin is a topical antibiotic developed by GlaxoSmithKline. Retapamulin(SB-275833) is the first drug in the new class of pleuromutilin antibiotics to be approved for human use.Retapamulin(SB-275833) is marketed as an ointment under the brand names Altabax and Altargo. Retapamulin(SB-275833) is useful for Antibiotics.
Related Catalog
References

[1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60.

[2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30.

[3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8.

[4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204.

[5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 594.9±50.0 °C at 760 mmHg
Molecular Formula C30H47NO4S
Molecular Weight 517.763
Flash Point 313.6±30.1 °C
Exact Mass 517.322571
PSA 92.14000
LogP 5.45
Vapour Pressure 0.0±3.8 mmHg at 25°C
Index of Refraction 1.571
Storage condition 2~8℃

 Safety Information

Hazard Codes Xi
HS Code 2933990090

 Synthetic Route

8-Methyl-8-azabicyclo[3.2.1]octane-3-thiol structure

8-Methyl-8-azab...

CAS#:848130-83-6

Pleuromutilin-22-mesylate structure

Pleuromutilin-2...

CAS#:60924-38-1

~81%

Retapamulin Structure

Retapamulin

CAS#:224452-66-8

Literature: Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; Shachan-Tov, Sharona Patent: US2009/149655 A1, 2009 ; Location in patent: Page/Page column 3; 5; 6 ;

 Precursor & DownStream

Precursor  2

DownStream  0

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Rebapamulin
Altabax
Altargo
(1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl {[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate
MFCD11045316
Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
Retapamulin
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