瑞他莫林

更新时间：2024-01-03 11:30:14

瑞他莫林结构式	常用名	瑞他莫林	英文名	Retapamulin
	CAS号	224452-66-8	分子量	517.763
	密度	1.2±0.1 g/cm3	沸点	594.9±50.0 °C at 760 mmHg
	分子式	C₃₀H₄₇NO₄S	熔点	N/A
	MSDS	N/A	闪点	313.6±30.1 °C

瑞他莫林用途

Retapamulin(SB-275833)是局部抗生素，能结合金黄色葡萄球菌和大肠杆菌核糖体，Kd为3 nM。

中文名	瑞他莫林
英文名	Retapamulin
中文别名	瑞他帕林
英文别名	更多

描述	Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。
相关类别	信号通路 >> 抗感染 >> 细菌研究领域 >> 其他
参考文献	[1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60. [2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30. [3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8. [4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204. [5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517.

描述

Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。

相关类别

信号通路 >> 抗感染 >> 细菌

研究领域 >> 其他

参考文献

[1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60.

[2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30.

[3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8.

[4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204.

[5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517.

密度	1.2±0.1 g/cm3
沸点	594.9±50.0 °C at 760 mmHg
分子式	C₃₀H₄₇NO₄S
分子量	517.763
闪点	313.6±30.1 °C
精确质量	517.322571
PSA	92.14000
LogP	5.45
蒸汽压	0.0±3.8 mmHg at 25°C
折射率	1.571
储存条件	2~8℃

危害码 (欧洲)	Xi
海关编码	2933990090

8-Methyl-8-azab...

848130-83-6

截短侧耳素-22-甲磺酸酯

60924-38-1

~81%

瑞他莫林

224452-66-8

文献：Hedvati, Lilach; Gilboa, Eyal; Avhar-Maydan, Sharon; Shachan-Tov, Sharona Patent: US2009/149655 A1, 2009 ; Location in patent: Page/Page column 3; 5; 6 ;

瑞他莫林上游产品 2
CAS号848130-83-6 8-Methyl-8-azab... CAS号60924-38-1 截短侧耳素-22-甲磺酸酯
瑞他莫林下游产品 0

海关编码	2933990090
中文概述	2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
申报要素	品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Rebapamulin

Altabax

Altargo

(1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl {[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate

MFCD11045316

Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester

Retapamulin