瑞他莫林

• 常用名: 瑞他莫林
• 英文名: Retapamulin
• CAS号: 224452-66-8
• 分子量: 517.763
• 密度: 1.2±0.1 g/cm3
• 沸点: 594.9±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₇NO₄S
• 熔点: N/A
• 闪点: 313.6±30.1 °C

瑞他莫林用途

Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。

瑞他莫林名称

• 中文名: 瑞他莫林
• 英文名: Retapamulin
• 中文别名: 瑞他帕林

瑞他莫林生物活性

• 描述: Retapamulin(SB-275833)是局部抗生素,能结合金黄色葡萄球菌和大肠杆菌核糖体,Kd为3 nM。
• 相关类别:
  信号通路 >> 抗感染 >> 细菌
  研究领域 >> 其他
• 参考文献:

  [1]. Kircik LH. Efficacy and tolerability of retapamulin 1% ointment for the treatment of infected atopic dermatitis: a pilot study. J Drugs Dermatol. 2012 Jul 1;11(7):858-60.

  [2]. Candel FJ, Morales G, Picazo JJ. In vitro activity of retapamulin against linezolid and methicillin-resistant Staphylococcus aureus isolates. Rev Esp Quimioter. 2011 Sep;24(3):127-30.

  [3]. Pérez-Trallero E, Tamayo E, Montes M, García-Arenzana JM, Iriarte V. In vitro activities of retapamulin and 16 other antimicrobial agents against recently obtained Streptococcus pyogenes isolates. Antimicrob Agents Chemother. 2011 May;55(5):2406-8.

  [4]. Weinberg JM, Tyring SK. Retapamulin: an antibacterial with a novel mode of action in an age of emerging resistance to Staphylococcus aureus. J Drugs Dermatol. 2010 Oct;9(10):1198-204.

  [5]. Retapamulin: focus on its use in the treatment of uncomplicated superficial skin infections and impetigo By Jacobs, Michael R.From Expert Review of Dermatology (2010), 5(5), 505-517.

瑞他莫林物理化学性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 594.9±50.0 °C at 760 mmHg
• 分子式: C₃₀H₄₇NO₄S
• 分子量: 517.763
• 闪点: 313.6±30.1 °C
• 精确质量: 517.322571
• PSA: 92.14000
• LogP: 5.45
• InChIKey: STZYTFJPGGDRJD-RVYJGNDLSA-N
• SMILES: C=CC1(C)CC(OC(=O)CSC2CC3CCC(C2)N3C)C2(C)C(C)CCC3(CCC(=O)C32)C(C)C1O
• 蒸汽压: 0.0±3.8 mmHg at 25°C
• 折射率: 1.571
• 储存条件: 2~8℃

瑞他莫林安全信息

• 危害码 (欧洲): Xi
• 海关编码: 2933990090

瑞他莫林海关

• 海关编码: 2933990090
• 中文概述: 2933990090. 其他仅含氮杂原子的杂环化合物. 增值税率:17.0%. 退税率:13.0%. 监管条件:无. 最惠国关税:6.5%. 普通关税:20.0%
• 申报要素: 品名, 成分含量, 用途, 乌洛托品请注明外观, 6－己内酰胺请注明外观, 签约日期
• Summary: 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

瑞他莫林靶点实验

查看更多实验

实验名称：Antibacterial activity against pleuromutilin-resistant Enterococcus faecium 18SC29-2 ... 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL5615744

实验名称：Antibacterial activity against pleuromutilin-resistant Enterococcus faecium 18FJZ1-1 ... 来源：ChEMBL 靶标：Enterococcus faecium External Id：CHEMBL5615745

实验名称：Antibacterial activity against methicillin-resistant Staphylococcus aureus J1 harbori... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL5615746

实验名称：Antibacterial activity against pleuromutilin-resistant Staphylococcus simulans isolat... 来源：ChEMBL 靶标：Staphylococcus simulans External Id：CHEMBL5615747

实验名称：Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020);... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL4296184

实验名称：Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); ... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL4296186

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CA... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL4296185

实验名称：Antibacterial activity against Streptococcus pneumoniae by agar microdilution method 来源：ChEMBL 靶标：Streptococcus pneumoniae External Id：CHEMBL1944430

实验名称：Displacement of [3H]SB-2587891 from Escherichia coli ribosomes 来源：ChEMBL 靶标：N/A External Id：CHEMBL922293

实验名称：Antimicrobial activity against Streptococcus pyogenes 来源：ChEMBL 靶标：Streptococcus pyogenes External Id：CHEMBL922295

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瑞他莫林英文别名

• Rebapamulin
• Altabax
• Altargo
• (1S,2R,3S,4S,6R,7R,8R,14R)-3-Hydroxy-2,4,7,14-tetramethyl-9-oxo-4-vinyltricyclo[5.4.3.0]tetradec-6-yl {[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]sulfanyl}acetate
• MFCD11045316
• Acetic acid, 2-[[(3-exo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]thio]-, (3aS,4R,5S,6S,8R,9R,9aR,10R)-6-ethenyldecahydro-5-hydroxy-4,6,9,10-tetramethyl-1-oxo-3a,9-propano-3aH-cyclopentacycloocten-8-yl ester
• Retapamulin