Clozapine N-oxide dihydrochloride structure
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Common Name | Clozapine N-oxide dihydrochloride | ||
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CAS Number | 2250025-93-3 | Molecular Weight | 415.74 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H21Cl3N4O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Clozapine N-oxide dihydrochlorideClozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride specifically activates the DREADD receptor hM3Dq. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[4][5]. |
Name | Clozapine N-oxide dihydrochloride |
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Description | Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride specifically activates the DREADD receptor hM3Dq. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier[1][2][3]. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist[4][5]. |
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Related Catalog | |
Target |
Human muscarinic designer receptors (DREADDs)[1] |
In Vitro | Clozapine N-oxide (CNO) can bind to non-DREADD receptors at concentrations required for DREADD activation, and undergoes reverse-metabolism to its parent compound clozapine, an atypical antipsychotic that acts at a variety of pharmacological targets and produces numerous physiological and behavioral effects[2]. |
In Vivo | After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h)[1]. |
References |
Molecular Formula | C18H21Cl3N4O |
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Molecular Weight | 415.74 |