DJ-V-159

Modify Date: 2024-09-17 08:43:57

DJ-V-159 structure	Common Name	DJ-V-159
	CAS Number	2253744-53-3	Molecular Weight	502.37
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₁₂F₆N₄O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of DJ-V-159

DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).

Name	DJ-V-159

Description	DJ-V-159 is an agonist for G protein-coupled receptor family C group 6 member A (GPRC6A).
Related Catalog	Signaling Pathways >> Others >> Androgen Receptor Research Areas >> Metabolic Disease
Target	GPRC6A[1].
In Vitro	DJ-V-159 activates ERK in HEK-293 transfected with GPRC6A but not in non-transfected HEK-293 cells, with potency similar to L-Arg. In addition, DJ-V-159 dose-dependently stimulates cAMP production in GPRC6A expressing HEK-293 cells, achieving a response a 0.2 nM concentrations in the media. DJ-V-159 stimulates insulin secretion in mouse beta-cell MIN-6 cells. The DJ-V-159 increased insulin stimulation index (SI) in MIN-6 cells similar to the effects of Ocn, known ligand of GPRC6A[1].
In Vivo	DJ-V-159 at the dose of 10 mg/kg reduces blood glucose levels in wildtype mice at 60 and 90 minutes after intraperitoneal administration of 10 mg/kg, whereas the vehicle (95% PEG + 5% DMSO) has no effect on blood glucose. DJ-V-159 reduces blood glucose levels in wild-type mice by 43.6% and 41.9% at 60 and 90 minutes, respectively, after intraperitoneal administration of 10 mg/kg. The mice tolerated this short-term exposure to DJ-V-159 without any overt side-effects. DJ-V-159, however, is almost in or on the boundary of the Lipinski's Rule of Five[1].
Animal Admin	Mice[1] 8 to 10 weeks ago wild type C57BL/6 mice are fasted for 5 hours, injected ip with ${DJ-V-159} (10 mg/kg body weight), or Metformin (300 mg/kg body weight), or vehicle (95% PEG + 5% DMSO; 10 μL/g body weight). Blood glucose levels are measured at 0, 30, 60 and 90 minutes after injection[1].
References	[1]. Pi M, et al. Computationally identified novel agonists for GPRC6A. PLoS One. 2018 Apr 23;13(4):e0195980.

Molecular Formula	C₂₄H₁₂F₆N₄O₂
Molecular Weight	502.37
Storage condition	2-8℃

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: DJ-V-159
Price: Negotiable
Purity: 99.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: DJ-V-159
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: DJ-V-159
Price: $550.0/100mg $950.0/250mg $1800.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥774/10 mM * 1 mL in DMSO

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