alexidine

Modify Date: 2024-01-02 09:56:58

alexidine structure	Common Name	alexidine
	CAS Number	22573-93-9	Molecular Weight	581.712
	Density	1.1±0.1 g/cm3	Boiling Point	574.5±60.0 °C at 760 mmHg
	Molecular Formula	C₂₆H₅₈Cl₂N₁₀	Melting Point	220-224ºC
	MSDS	N/A	Flash Point	301.3±32.9 °C

Use of alexidine

Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].

Name	alexidine
Synonym	More Synonyms

Description	Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	With the treatment of Alexidine (10 µM, 24 hours), biofilm community can be decimated[1]. .With the treatment of Alexidine (0-60 μg/ml, 24 hours), Alexidine can kill HUVECs and lung A549 cells[1]. Cell Viability Assay Cell Line: C. albicans, C. auris, A. fumigatus[1] Concentration: 10 µM Incubation Time: 24 hours Result: Could significantly kill 80% of mature biofilm community. Cell Viability Assay Cell Line: HUVECs, lung A549 cells[1] Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ).
In Vivo	With the treatment of Alexidine (Jugular vein-catheterized, 48 hours, 3 µg/ml, once) for 48 hours, Alexidine can decimate preformed biofilms growing in the jugular vein catheters of mice[1]. Animal Model: 8-week-old C57BL/6 male mice Dosage: 3 µg/ml Administration: Jugular vein-catheterized, 48 hours, 3 µg/ml, once Result: Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
References	[1]. Zeinab Mamouei, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 Oct 31;3(5):e00539-18.

Density	1.1±0.1 g/cm3
Boiling Point	574.5±60.0 °C at 760 mmHg
Melting Point	220-224ºC
Molecular Formula	C₂₆H₅₈Cl₂N₁₀
Molecular Weight	581.712
Flash Point	301.3±32.9 °C
Exact Mass	580.422302
PSA	167.58000
LogP	4.56
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.551
Storage condition	2-8℃

Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
HS Code	29224995

Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(2-ethylhexyl)-, hydrochloride (1:2)

1,1'-Hexamethylene-bis[5-(2-ethylhexyl)biguanide] dihydrochloride

N,N''''-1,6-Hexanediylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)]

Sterwin 904

UNII:I2A7616PY1

alexidine 2HCl

1,1'-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)

Bisguanidine

Prestwick_42

N,N''''-1,6-Hexanediylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] dihydrochloride

n,n''''-hexane-1,6-diylbis[n'-(2-ethylhexyl)(imidodicarbonimidic diamide)] dihydrochloride

Alexidine dihydrochloride

Bisguadine

Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(2-ethylhexyl)-

N,N''''-Hexane-1,6-diylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)]

Alexidine.2HCl

alexidine

QR-711

1,1'-HEXAMETHYLENE-BIS[5-(2-ETHYLHEXYL)BIGUANIDE]

Compound-904

alexidine

Use of alexidine

Names

alexidine Biological Activity

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