22573-93-9

22573-93-9 structure

Name: alexidine
Chemical Name: alexidine
CAS Number: 22573-93-9
Molecular Formula: C₂₆H₅₈Cl₂N₁₀
Molecular Weight: 581.712
Catalog: Chemical reagent Organic reagent Barium salt
Create Date: 2018-08-27 10:43:51
Modify Date: 2024-01-02 09:56:58
Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].

Name	alexidine
Synonyms	Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(2-ethylhexyl)-, hydrochloride (1:2) 1,1'-Hexamethylene-bis[5-(2-ethylhexyl)biguanide] dihydrochloride N,N''''-1,6-Hexanediylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] Sterwin 904 UNII:I2A7616PY1 alexidine 2HCl 1,1'-Hexamethylene-bis(5-[2-ethylhexyl]biguanide) Bisguanidine Prestwick_42 N,N''''-1,6-Hexanediylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] dihydrochloride n,n''''-hexane-1,6-diylbis[n'-(2-ethylhexyl)(imidodicarbonimidic diamide)] dihydrochloride Alexidine dihydrochloride Bisguadine Imidodicarbonimidic diamide, N,N''''-1,6-hexanediylbis[N'-(2-ethylhexyl)- N,N''''-Hexane-1,6-diylbis[N'-(2-ethylhexyl)(imidodicarbonimidic diamide)] Alexidine.2HCl alexidine QR-711 1,1'-HEXAMETHYLENE-BIS[5-(2-ETHYLHEXYL)BIGUANIDE] Compound-904

Description	Alexidine, a bis-biguanide, exhibits antifungal and antibiofilm activity against a diverse range of fungal pathogens. Alexidine is an anticancer agent that targets a mitochondrial tyrosine phosphatase, PTPMT1, in mammalian cells and causes mitochondrial apoptosis[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	With the treatment of Alexidine (10 µM, 24 hours), biofilm community can be decimated[1]. .With the treatment of Alexidine (0-60 μg/ml, 24 hours), Alexidine can kill HUVECs and lung A549 cells[1]. Cell Viability Assay Cell Line: C. albicans, C. auris, A. fumigatus[1] Concentration: 10 µM Incubation Time: 24 hours Result: Could significantly kill 80% of mature biofilm community. Cell Viability Assay Cell Line: HUVECs, lung A549 cells[1] Concentration: 0-60 μg/ml Incubation Time: 24 hours Result: resulted in 50% killing of HUVECs and lung A549 cells ( CC50 > 7.37 μg/ml ).
In Vivo	With the treatment of Alexidine (Jugular vein-catheterized, 48 hours, 3 µg/ml, once) for 48 hours, Alexidine can decimate preformed biofilms growing in the jugular vein catheters of mice[1]. Animal Model: 8-week-old C57BL/6 male mice Dosage: 3 µg/ml Administration: Jugular vein-catheterized, 48 hours, 3 µg/ml, once Result: Inhibited 67% of fungal biofilm growth and viability, compared to the control untreated biofilms.
References	[1]. Zeinab Mamouei, et al. Alexidine Dihydrochloride Has Broad-Spectrum Activities against Diverse Fungal Pathogens. mSphere. 2018 Oct 31;3(5):e00539-18.

Density	1.1±0.1 g/cm3
Boiling Point	574.5±60.0 °C at 760 mmHg
Melting Point	220-224ºC
Molecular Formula	C₂₆H₅₈Cl₂N₁₀
Molecular Weight	581.712
Flash Point	301.3±32.9 °C
Exact Mass	580.422302
PSA	167.58000
LogP	4.56
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.551
Storage condition	2-8℃

Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	26-36
HS Code	29224995