FC-11

• 常用名: FC-11
• 英文名: FC-11
• CAS号: 2271035-37-9
• 分子量: 949.91
• 密度: N/A
• 沸点: N/A
• 分子式: C₄₁H₄₂F₃N₁₃O₉S
• 熔点: N/A
• 闪点: N/A

FC-11用途

FC-11是PROTAC FAK降解剂(DC90:1 nM)。FC-11含有CRBN配体泊马度胺(HY-10984)、接头和FAK配体PF562271(HY-10459)。FC-11在各种细胞中降解FAK,TM3中的DC50为310 pM,PA1中的DC50s为80 pM,MDA-MB-436中为330 pM,LNCaP中为370 pM,Ramos细胞中为40 pM[1]。

FC-11名称

• 英文名: FC-11

FC-11生物活性

• 描述: FC-11是PROTAC FAK降解剂(DC90:1 nM)。FC-11含有CRBN配体泊马度胺(HY-10984)、接头和FAK配体PF562271(HY-10459)。FC-11在各种细胞中降解FAK,TM3中的DC50为310 pM,PA1中的DC50s为80 pM,MDA-MB-436中为330 pM,LNCaP中为370 pM,Ramos细胞中为40 pM[1]。
• 相关类别:
  研究领域 >> 癌症
  信号通路 >> 蛋白酪氨酸激酶 >> FAK
  信号通路 >> 蛋白裂解靶向嵌合体 >> PROTAC
• 参考文献:

  [1]. Gao H, et al. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862. Gao H, Wu Y, Sun Y, Yang Y, Zhou G, Rao Y. Design, Synthesis, and Evaluation of Highly Potent FAK-Targeting PROTACs. ACS Med Chem Lett. 2019 Oct 22;11(10):1855-1862.

FC-11物理化学性质

• 分子式: C₄₁H₄₂F₃N₁₃O₉S
• 分子量: 949.91
• InChIKey: RZKZQCHSKWKOAJ-UHFFFAOYSA-N
• SMILES: CN(c1ncccc1CNc1nc(Nc2ccc(NC(=O)c3cn(CCOCCOCCNc4cccc5c4C(=O)N(C4CCC(=O)NC4=O)C5=O)nn3)cc2)ncc1C(F)(F)F)S(C)(=O)=O

FC-11靶点实验

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实验名称：Protac activity at CRBN/FAK in mouse TM3 cells assessed as reduction in FAK autophosp... 来源：ChEMBL 靶标：Focal adhesion kinase 1 External Id：CHEMBL4730721

实验名称：Protac activity at CRBN/FAK in human PA1 cells assessed as induction of FAK degradati... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4730722

实验名称：Protac activity at CRBN/FAK in human PA1 cells assessed as FAK degradation at 1 to 10... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4730725

实验名称：Protac activity at CRBN/FAK in human PA1 cells assessed as induction of FAK degradati... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4730723

实验名称：Protac activity at CRBN/FAK in human PA1 cells assessed as FAK degradation at 1 to 10... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL4730724

实验名称：Protac activity at CRBN E3 ligase/FAK (unknown origin) assessed as inhibition of FAK ... 来源：ChEMBL 靶标：Protein cereblon External Id：CHEMBL5333478

实验名称：Antiproliferative activity against mouse TM3 cells assessed as effect on cell prolife... 来源：ChEMBL 靶标：TM3 External Id：CHEMBL4730737

实验名称：Antiproliferative activity against human PA1 cells assessed as effect on cell prolife... 来源：ChEMBL 靶标：PA-1 External Id：CHEMBL4730738

实验名称：Protac activity at CRBN/FAK in mouse TM3 cells assessed as reduction in FAK autophosp... 来源：ChEMBL 靶标：Focal adhesion kinase 1 External Id：CHEMBL4730736

实验名称：Antiproliferative activity against human Ramos cells assessed as effect on cell proli... 来源：ChEMBL 靶标：Ramos External Id：CHEMBL4730741

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