UBX1325

Modify Date: 2024-01-05 18:40:33

UBX1325 Structure
UBX1325 structure
Common Name UBX1325
CAS Number 2271269-01-1 Molecular Weight 1159.69
Density N/A Boiling Point N/A
Molecular Formula C53H59ClF3N6O10PS3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of UBX1325


UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1].

 Names

Name UBX1325

 UBX1325 Biological Activity

Description UBX1325 is an Bcl-xL inhibitor that promotes apoptosis in senescent cells. UBX1325 is a potent anti-aging agent that can be used in studies of age-related eye diseases such as diabetic macular oedema (DME), age-related macular degeneration (AMD) and diabetic retinopathy (DR)[1].
Related Catalog
In Vitro UBX1325 leads to a decrease in the anti-apoptotic Bcl-xL:Bim complex in retina by intravitreal (IVT) injection administration in oxygen induced retinopathy (OIR) C57BL/6 mice model[1]. UBX1325 can cause a decrease in retinal vascular permeability and promote retinal neovascularization in streptozotocin (STZ)-induced retinopathy mice model[1].
References

[1]. Pamela Tsuruda, et al. UBX1325, a small molecule inhibitor of Bcl-xL, attenuates vascular dysfunction in two animal models of retinopathy. Investigative Ophthalmology & Visual Science June 2021,Volume 62, Issue 8

 Chemical & Physical Properties

Molecular Formula C53H59ClF3N6O10PS3
Molecular Weight 1159.69