HL-43
Modify Date: 2024-01-11 22:45:32
HL-43 structure
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Common Name | HL-43 | ||
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| CAS Number | 2287258-85-7 | Molecular Weight | 474.492 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H23FN4O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HL-43HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models. |
| Name | HL-43 |
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| Description | HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models. |
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| References | 1. Yunyun Jin, et al. Cell Discov. 2022 Mar 8;8(1):24. |
| Molecular Formula | C26H23FN4O4 |
|---|---|
| Molecular Weight | 474.492 |