2287258-85-7

2287258-85-7 structure

Name: HL-43
Chemical Name: HL-43
CAS Number: 2287258-85-7
Molecular Formula: C₂₆H₂₃FN₄O₄
Molecular Weight: 474.492
Create Date: 2022-07-01 12:13:10
Modify Date: 2024-01-11 22:45:32
HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models.

Name	HL-43

Description	HL-43 (EP4 antagonist HL-43) is a selective prostaglandin E receptor 4 (EP4) antagonist, promotes chondrocyte differentiation/cartilage regeneration and anabolism with low toxicity;HL-43 exhibits the highest potency in inducing Col2a1 expression and reducing Mmp3 expression in presence of IL-1β.HL-43 downregulats Mmp3/13 expression in a dose-dependent manner.HL-43 induces anabolic factors (ACAN and SOX9), and suppresses catabolic factor (MMP13), and hypertrophic marker (COLX), inhibits the STAT3 catabolic pathway;.HL-43 promotes chondrocyte differentiation and ECM generation, and inhibits matrix degradation in both human and mouse articular cartilage explants.HL-43 enhances cartilage repair and regeneration in different artilage defect (CD) animal models.
References	1. Yunyun Jin, et al. Cell Discov. 2022 Mar 8;8(1):24.

Molecular Formula	C₂₆H₂₃FN₄O₄
Molecular Weight	474.492