BuChE-IN-TM-10

Modify Date: 2024-02-04 10:22:26

BuChE-IN-TM-10 Structure
BuChE-IN-TM-10 structure
Common Name BuChE-IN-TM-10
CAS Number 2313524-95-5 Molecular Weight 498.66
Density N/A Boiling Point N/A
Molecular Formula C32H38N2O3 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of BuChE-IN-TM-10


BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer’s disease[1].

 Names

Name BuChE-IN-TM-10

 BuChE-IN-TM-10 Biological Activity

Description BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM. BuChE inhibitor 1 inhibits and disaggregates self-induced Aβ aggregation, exhibiting potent antioxidant activity and good blood-brain barrier (BBB) penetration. Has potential to treat Alzheimer’s disease[1].
Related Catalog
Target

IC50: 8.9 nM (BuChE)[1].

References

[1]. Sang Z, et al. Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease. ACS Chem Neurosci. 2019 Feb 20;10(2):1008-1024.

 Chemical & Physical Properties

Molecular Formula C32H38N2O3
Molecular Weight 498.66