LEI110(LEI-110
Modify Date: 2025-08-25 17:22:02
LEI110(LEI-110 structure
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Common Name | LEI110(LEI-110 | ||
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| CAS Number | 2313525-90-3 | Molecular Weight | 456.465 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H23F3N2O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of LEI110(LEI-110LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells; LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT). |
| Name | LEI110 |
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| Description | LEI110 (LEI-110) is a potent Phospholipase A2 group XVI (PLA2G16) inhibitor with Ki of 20 nM, also has activity on HRASLS2, RARRES3 and iNAT (pIC50=6.8-7.6); reduces cellular arachidonic acid levels and oleic acid-induced lipolysis in human HepG2 cells; LEI110 is a selective pan-inhibitor of the HRASLS-family of thiol hydrolases (i.e. PLA2G16, HRASLS2, RARRES3 and iNAT). |
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| References | References 1. Zhou J, et al. ACS Chem Biol. 2019 Jan 8. doi: 10.1021/acschembio.8b00969. View Related Products by Target Phospholipase |
| Molecular Formula | C25H23F3N2O3 |
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| Molecular Weight | 456.465 |
| InChIKey | DZHZISUSQMPBJQ-UHFFFAOYSA-N |
| SMILES | O=C(CCCc1ccccc1)C(=O)NCCc1ccc(Oc2ccc(C(F)(F)F)cn2)cc1 |