Paeoniflorin

Modify Date: 2024-01-01 18:54:45

Paeoniflorin Structure
Paeoniflorin structure
 Common Name Paeoniflorin
CAS Number 23180-57-6 Molecular Weight 480.462
Density 1.6±0.1 g/cm3 Boiling Point 690.2±55.0 °C at 760 mmHg
Molecular Formula C23H28O11 Melting Point N/A
MSDS Chinese USA Flash Point 238.4±25.0 °C

 Use of Paeoniflorin


Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3].

 Names

Name Paeoniflorin
Synonym More Synonyms

 Paeoniflorin Biological Activity

Description Paeoniflorin is a herbal constituent extracted from the root of Paeonia albiflora Pall.Target: OthersPaeoniflorin (PF) is the principal bioactive component of Radix Paeo- niae alba, which is widely used in Traditional Chinese Medicine for the treatment of neurodegenerative disorders such as Parkinson's disease(PD) [1]. Paeoniflorin, a compound found in white peony that inhibited the production of testosterone and promoted the activity of aromatase, which converts testosterone into estrogen [2]. Treatment of cells with paeoniflorin but not glycyrrhizin resulted in enhanced phosphorylation and acquisition of the deoxyribonucleic acid-binding ability of heat shock transcription factor 1 (HSF1), as well as the formation of characteristic HSF1 granules in the nucleus, suggesting that the induction of HSPs by paeoniflorin is mediated by the activation of HSF1. Also, thermotolerance was induced by treatment with paeoniflorin but not glycyrrhizin. Paeoniflorin had no toxic effect at concentrations as high as 80 microg/ mL (166.4 microM). To our knowledge, this is the first report on the induction of HSPs by herbal medicines [3].
Related Catalog
References

[1]. Cao, B.Y., et al., Paeoniflorin, a potent natural compound, protects PC12 cells from MPP+ and acidic damage via autophagic pathway. J Ethnopharmacol, 2010. 131(1): p. 122-9.

[2]. Takeuchi, T., et al., Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med, 1991. 19(1): p. 73-8.

[3]. Yan, D., et al., Paeoniflorin, a novel heat shock protein-inducing compound. Cell Stress Chaperones, 2004. 9(4): p. 378-89.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 690.2±55.0 °C at 760 mmHg
Molecular Formula C23H28O11
Molecular Weight 480.462
Flash Point 238.4±25.0 °C
Exact Mass 480.163147
PSA 164.37000
LogP -0.42
Vapour Pressure 0.0±2.3 mmHg at 25°C
Index of Refraction 1.683
Storage condition room temp

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RT1200000
CHEMICAL NAME :
Paeoniflorin
CAS REGISTRY NUMBER :
23180-57-6
LAST UPDATED :
199112
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C23-H28-O11
MOLECULAR WEIGHT :
480.51

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3530 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity)
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,899,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9530 mg/kg
TOXIC EFFECTS :
Behavioral - sleep Behavioral - somnolence (general depressed activity)
REFERENCE :
YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 89,899,1969

 Preparation


 Customs

HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Paeoniae radix is one of the most important crude drugs used in Kampo medicines (KMs). A part of its pharmaceutical properties is due to the presence of paeoniflorin (PF) and albiflorin (AF).For the s...

 Synonyms

paeoniflorine
Paeony root
Delmacinone
Paeonia moutan
peoniflorin
MFCD00869331
Paeonia lactiflora P,E,
Paeoniflorm
EINECS 245-476-2
PAEONIFLORIN(P)
,Peoniflorin
PACLITAXEL
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