Thalidomide 4'-ether-alkylC2-amine hydrochloride

Modify Date: 2024-01-11 11:08:11

Thalidomide 4'-ether-alkylC2-amine hydrochloride structure	Common Name	Thalidomide 4'-ether-alkylC2-amine hydrochloride
	CAS Number	2341840-99-9	Molecular Weight	353.76
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₅H₁₆ClN₃O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Thalidomide 4'-ether-alkylC2-amine hydrochloride

Pomalidomide-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology[1].

Name	Pomalidomide-PEG1-NH2 hydrochloride

Description	Pomalidomide-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552‐7556.

Molecular Formula	C₁₅H₁₆ClN₃O₅
Molecular Weight	353.76

Hazard Codes	Xi

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.