2341840-99-9

2341840-99-9 structure

Name: Thalidomide 4'-ether-alkylC2-amine hydrochloride
Chemical Name: Pomalidomide-PEG1-NH2 hydrochloride
CAS Number: 2341840-99-9
Molecular Formula: C₁₅H₁₆ClN₃O₅
Molecular Weight: 353.76
Catalog: Signaling Pathways PROTAC E3 Ligase Ligand-Linker Conjugate
Create Date: 2020-08-10 20:11:21
Modify Date: 2024-01-11 11:08:11
Pomalidomide-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology[1].

Name	Pomalidomide-PEG1-NH2 hydrochloride

Description	Pomalidomide-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> E3 Ligase Ligand-Linker Conjugate
Target	Cereblon
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
References	[1]. Turk BE, et al. Binding of thalidomide to alpha1-acid glycoprotein may be involved in its inhibition of tumor necrosis factor alpha production. Proc Natl Acad Sci U S A. 1996;93(15):7552‐7556.

Molecular Formula	C₁₅H₁₆ClN₃O₅
Molecular Weight	353.76

Hazard Codes	Xi