CTCB-405

Modify Date: 2024-04-08 18:33:36

CTCB-405 Structure
CTCB-405 structure
Common Name CTCB-405
CAS Number 2342614-58-6 Molecular Weight 364.27
Density N/A Boiling Point N/A
Molecular Formula C18H19Cl2N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CTCB-405


CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.

 Names

Name CTCB-405

 CTCB-405 Biological Activity

Description CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.
References 1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052.

 Chemical & Physical Properties

Molecular Formula C18H19Cl2N3O
Molecular Weight 364.27
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