CTCB-405

Modify Date: 2024-04-08 18:33:36

CTCB-405 Structure
CTCB-405 structure
Common Name CTCB-405
CAS Number 2342614-58-6 Molecular Weight 364.27
Density N/A Boiling Point N/A
Molecular Formula C18H19Cl2N3O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of CTCB-405


CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.

 Names

Name CTCB-405

 CTCB-405 Biological Activity

Description CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.
References 1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052.

 Chemical & Physical Properties

Molecular Formula C18H19Cl2N3O
Molecular Weight 364.27
Top Suppliers:I want be here


Get all suppliers and price by the below link:

CTCB-405 suppliers

CTCB-405 price

Related Compounds: More...
SAR-405
1523406-39-4
Chromate(2-), [2,4-dihydro-4-[(2-hydroxy-4-nitrophenyl)azo]-5-methyl-2-phenyl-3H-pyrazol-3-onato(2-)][4-[(4,5-dihydro-3-methyl-5-oxo-1-phenyl-1H-pyrazol-4-yl)azo]-3-hydroxy-1-naphthalenesulfonato(3-)]-, disodium
83833-37-8
EML-405
2101954-79-2
RSVA 405
140405-36-3
6-[2,6-bis(2,4-dimethylphenyl)-1H-1,3,5-triazin-4-ylidene]-3-[3-(2-ethylhexoxy)-2-hydroxypropoxy]cyclohexa-2,4-dien-1-one
137658-79-8
disodium,4-(benzenesulfonyloxy)-5-[[4-[(5-hydroxy-7-sulfonatonaphthalen-2-yl)carbamoylamino]-5-methoxy-2-methylphenyl]diazenyl]-7-sulfonaphthalene-2-sulfonate
83949-44-4
Triton X-405, reduced
92046-34-9
disodium,4-[(5-chloro-6-methyl-2-methylsulfonylpyrimidin-4-yl)amino]-2-[(2E)-2-[5-imino-3-methyl-1-(3-sulfonatophenyl)pyrazol-4-ylidene]hydrazinyl]benzenesulfonate
83399-92-2
2-(6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)ethyl-trimethylazanium,4-methylbenzenesulfonate
130573-32-9
4-(2-Chloro-6-methylpyridin-3-yl)-1,3-oxazolidin-2-one
2228526-57-4
3-(1-Ethylcyclobutyl)-2-oxopropanoic acid
2021435-50-5
4,5-Dihydroxy-1-[(prop-2-en-1-yloxy)carbonyl]piperidine-3-carboxylic acid
2680888-63-3
2-[(2R)-1-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoyl]piperidin-2-yl]acetic acid
2308477-46-3
benzyl N-[5-bromo-2-(pyridin-4-yl)pyrimidin-4-yl]carbamate
2680729-06-8
1-(4-methylphenyl)-5-(2,2,2-trifluoroacetyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridine-3-carboxylic acid
2680880-93-5
benzyl N-(5-sulfanyl-1,3,4-thiadiazol-2-yl)-N-[(thiophen-2-yl)methyl]carbamate
2680707-23-5
5-(3-Methylpyrazin-2-yl)-1,2-oxazol-4-amine
2228978-91-2
5-({[(Benzyloxy)carbonyl]amino}methyl)-2-(trifluoromethyl)benzoic acid
2580199-76-2
1-(3-Methyl-3-phenylbutyl)cyclopropan-1-ol
2228381-05-1