CTCB-405 structure
|
Common Name | CTCB-405 | ||
---|---|---|---|---|
CAS Number | 2342614-58-6 | Molecular Weight | 364.27 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C18H19Cl2N3O | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of CTCB-405CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model. |
Name | CTCB-405 |
---|
Description | CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model. |
---|---|
References | 1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052. |
Molecular Formula | C18H19Cl2N3O |
---|---|
Molecular Weight | 364.27 |