2342614-58-6

2342614-58-6 structure

Name: CTCB-405
Chemical Name: CTCB-405
CAS Number: 2342614-58-6
Molecular Formula: C₁₈H₁₉Cl₂N₃O
Molecular Weight: 364.27
Create Date: 2022-07-01 17:59:31
Modify Date: 2024-04-08 18:33:36
CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.

Name	CTCB-405

Description	CTCB-405 (CTCB405) is a small molecule allosteric inhibitor of T. brucei phosphofructokinase (TbPFK) with IC50 of 0.18 uM, ITC Kd of 92 nM, no significant inhibition of human PFKs.CTCB-405 demonstrated in vitro parasite killing potency of the bloodstream form of T. brucei strain Lister 427 (EC50=0.37 uM).CTCB-405 (50, 100 mg/kg) clear parasites in a stage 1 model of HAT infection with 1-day oral dosing and show reduction of parasitaemia in the brain in a pleiomorphic model.
References	1. Iain W McNae, et al. Nat Commun. 2021 Feb 16;12(1):1052.

Molecular Formula	C₁₈H₁₉Cl₂N₃O
Molecular Weight	364.27