Trypanothione synthetase-IN-1
Modify Date: 2024-04-03 19:47:55
Trypanothione synthetase-IN-1 structure
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Common Name | Trypanothione synthetase-IN-1 | ||
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| CAS Number | 2355349-41-4 | Molecular Weight | 785.83 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C40H38F3N7O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Trypanothione synthetase-IN-1Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1]. |
| Name | Trypanothione synthetase-IN-1 |
|---|
| Description | Trypanothione synthetase-IN-1 (Compound 1) is a competitive Leishmania infantum trypanothione synthetase (TryS) inhibitor with an IC50 of 14.8 μM when triamine spermidine is as polyamine S[1]. |
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| Related Catalog | |
| Target |
IC50: 14.8 μM (LiTryS, triamine spermidine as polyamine S), 16.2 μM (LiTryS, glutathionylspermidine as polyamine S)[1] |
| In Vitro | Trypanothione synthetase-IN-1 (Compound 1) (0-75 μM; 24 or 72 h) shows leishmanicidal activity with cytotoxicity[1]. Trypanothione synthetase-IN-1 competes with ATP and the polyamine substrate for binding to LiTryS[1]. Cell Cytotoxicity Assay[1] Cell Line: L. infantum, HepG2 Concentration: 0-75 μM Incubation Time: 24 h (L. infantum axenic amastigotes) or 72 h Result: Showed leishmanicidal activity with EC50s of 21.5 ± 2.4 μM and 13.5 ± 0.9 μM against axenic amastigotes and intracellular amastigotes, respectively. Showed cytotoxicity with a CC50 of 15.9 ± 0.4 μM against HepG2 cells. |
| References |
| Molecular Formula | C40H38F3N7O5S |
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| Molecular Weight | 785.83 |