RBN-3143
Modify Date: 2025-08-25 19:24:43
RBN-3143 structure
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Common Name | RBN-3143 | ||
|---|---|---|---|---|
| CAS Number | 2360853-16-1 | Molecular Weight | 449.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H28FN3O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of RBN-3143RBN-3143 is a potent and selective PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of inflammation[1]. |
| Name | RBN-3143 |
|---|
| Description | RBN-3143 is a potent and selective PARP14 inhibitor with an IC50 value of 4 nM. RBN-3143 inhibits PARP14-mediated ADP-ribosylation and stabilizes PARP14 in cell lines. RBN-3143 can be used in research of inflammation[1]. |
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| Related Catalog | |
| Target |
PARP14:4 nM (IC50) PARP10:1600 nM (IC50) PARP15:4200 nM (IC50) PARP4:42700 nM (IC50) PARP3:>100000 nM (IC50) PARP2:>100000 nM (IC50) PARP1:>100000 nM (IC50) |
| In Vivo | RBN-3143 (5 ug; 鼻内给药) 可改善类固醇耐药哮喘小鼠模型[1]。 Animal Model: Mouse of asthma models[1] Dosage: 5 ug Administration: Intranasal administration Result: Suppressed the accumulation of alarmins TSLP, IL-33, and IL-25. |
| References |
| Molecular Formula | C22H28FN3O4S |
|---|---|
| Molecular Weight | 449.54 |
| InChIKey | LLXIEISWIFSUBQ-UHFFFAOYSA-N |
| SMILES | CC(=O)N1CCC(COc2cc(F)c3c(=O)[nH]c(CSC4CCOCC4)nc3c2)CC1 |