SY-5102

Modify Date: 2024-01-11 18:03:50

SY-5102 Structure
SY-5102 structure
 Common Name SY-5102
CAS Number 2365230-48-2 Molecular Weight 457.45
Density N/A Boiling Point N/A
Molecular Formula C22H22F3N7O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SY-5102


SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.

 Names

Name SY-5102

 SY-5102 Biological Activity

Description SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.
References 1. Jason J Marineau, et al. J Med Chem. 2022 Jan 27;65(2):1458-1480.

 Chemical & Physical Properties

Molecular Formula C22H22F3N7O
Molecular Weight 457.45
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Chemsrc provides SY-5102(CAS#:2365230-48-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of SY-5102 are included as well.>> amp version: SY-5102

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