2365230-48-2
2365230-48-2 structure
- Name: SY-5102
- Chemical Name: SY-5102
- CAS Number: 2365230-48-2
- Molecular Formula: C22H22F3N7O
- Molecular Weight: 457.45
- Create Date: 2022-08-01 22:48:36
- Modify Date: 2024-01-11 18:03:50
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SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model.
| Name | SY-5102 |
|---|
| Description | SY-5102 (SY5102) is a highly potent, selective, noncovalent, orally available CDK7 inhibitor with SPR Kd of 0.03 nM (binding to CDK7/Cyclin H).SY-5102 (SY5102) displays highly selectivity against CDK2, CDK9, and CDK12 (all IC50>75 nM).SY-5102 potently inhibits HCC70 cell proliferation with EC50 of 9 nM.SY-5102 showed dose-dependent tumor growth inhibition including tumor regression at 4 mg/kg po (dosed twice daily) in an HCC70 cell line derived xenograft mouse model. |
|---|---|
| References | 1. Jason J Marineau, et al. J Med Chem. 2022 Jan 27;65(2):1458-1480. |
| Molecular Formula | C22H22F3N7O |
|---|---|
| Molecular Weight | 457.45 |