Pactamycin
Pactamycin structure
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Common Name | Pactamycin | ||
|---|---|---|---|---|
| CAS Number | 23668-11-3 | Molecular Weight | 558.62300 | |
| Density | 1.38g/cm3 | Boiling Point | 784.2ºC at 760mmHg | |
| Molecular Formula | C28H38N4O8 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 428.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of PactamycinPactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act |
| Name | Benzoic acid,2-hydroxy-6-methyl-,[(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methylester |
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| Synonym | More Synonyms |
| Density | 1.38g/cm3 |
|---|---|
| Boiling Point | 784.2ºC at 760mmHg |
| Molecular Formula | C28H38N4O8 |
| Molecular Weight | 558.62300 |
| Flash Point | 428.1ºC |
| Exact Mass | 558.26900 |
| PSA | 194.68000 |
| LogP | 1.91870 |
| Vapour Pressure | 6.66E-26mmHg at 25°C |
| Index of Refraction | 1.645 |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
MUTATION DATA
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| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300-H315-H319-H335 |
| Precautionary Statements | P261-P264-P301 + P310-P305 + P351 + P338 |
| RIDADR | UN 2811 6.1 / PGII |
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Enantioselective synthesis of pactamycin, a complex antitumor antibiotic.
Science 340(6129) , 180-2, (2013) Medicinal application of many complex natural products is precluded by the impracticality of their chemical synthesis. Pactamycin, the most structurally intricate aminocyclopentitol antibiotic, displa... |
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Total synthesis of pactamycin and pactamycate: a detailed account.
J. Org. Chem. 77(21) , 9458-72, (2012) This article describes synthetic studies that culminated in the first total synthesis of pactamycin and pactamycate and, in parallel, the two known congeners, de-6-MSA-pactamycin and de-6-MSA-pactamyc... |
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Diastereocontrolled construction of pactamycin's complex ureido triol functional array.
Org. Lett. 14(11) , 2878-81, (2012) An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea functionality allows for its participation in a diastereoselective, chelati... |
| Pactamycin |