密旋霉素

更新时间:2024-01-03 10:41:04

密旋霉素结构式
密旋霉素结构式
品牌特惠专场
常用名 密旋霉素 英文名 Pactamycin
CAS号 23668-11-3 分子量 558.62300
密度 1.38g/cm3 沸点 784.2ºC at 760mmHg
分子式 C28H38N4O8 熔点 N/A
MSDS 美版 闪点 428.1ºC
符号 GHS06
GHS06
信号词 Danger

 密旋霉素用途


Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act

 密旋霉素名称

中文名 密旋霉素
英文名 Benzoic acid,2-hydroxy-6-methyl-,[(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methylester
英文别名 更多

 密旋霉素物理化学性质

密度 1.38g/cm3
沸点 784.2ºC at 760mmHg
分子式 C28H38N4O8
分子量 558.62300
闪点 428.1ºC
精确质量 558.26900
PSA 194.68000
LogP 1.91870
蒸汽压 6.66E-26mmHg at 25°C
折射率 1.645

 密旋霉素毒性和生态

 密旋霉素安全信息

符号 GHS06
GHS06
信号词 Danger
危害声明 H300-H315-H319-H335
警示性声明 P261-P264-P301 + P310-P305 + P351 + P338
危险品运输编码 UN 2811 6.1 / PGII

 密旋霉素文献23

更多文献
Enantioselective synthesis of pactamycin, a complex antitumor antibiotic.

Science 340(6129) , 180-2, (2013)

Medicinal application of many complex natural products is precluded by the impracticality of their chemical synthesis. Pactamycin, the most structurally intricate aminocyclopentitol antibiotic, displa...

Total synthesis of pactamycin and pactamycate: a detailed account.

J. Org. Chem. 77(21) , 9458-72, (2012)

This article describes synthetic studies that culminated in the first total synthesis of pactamycin and pactamycate and, in parallel, the two known congeners, de-6-MSA-pactamycin and de-6-MSA-pactamyc...

Diastereocontrolled construction of pactamycin's complex ureido triol functional array.

Org. Lett. 14(11) , 2878-81, (2012)

An advanced intermediate in a projected synthesis of pactamycin has been prepared. Early installation of the C1-dimethylurea functionality allows for its participation in a diastereoselective, chelati...

 密旋霉素英文别名

Pactamycin
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