密旋霉素

• 常用名: 密旋霉素
• 英文名: Pactamycin
• CAS号: 23668-11-3
• 分子量: 558.62300
• 密度: 1.38g/cm3
• 沸点: 784.2ºC at 760mmHg
• 分子式: C₂₈H₃₈N₄O₈
• 熔点: N/A
• 闪点: 428.1ºC
• 符号: GHS06
• 信号词: Danger

密旋霉素用途

Pactamycin (NSC 52947) is a potent protein synthesis inhibitor, inhibits protein synthesis at the translocation step on the 70S ribosome, has activity against Gram-positive and Gram-negative bacteria, and broad antitumor, antiviral, and antiplasmodial act

密旋霉素名称

• 中文名: 密旋霉素
• 英文名: Benzoic acid,2-hydroxy-6-methyl-,[(1S,2R,3R,4S,5S)-5-[(3-acetylphenyl)amino]-4-amino-3-[[(dimethylamino)carbonyl]amino]-1,2-dihydroxy-3-[(1S)-1-hydroxyethyl]-2-methylcyclopentyl]methylester

密旋霉素物理化学性质

• 密度: 1.38g/cm3
• 沸点: 784.2ºC at 760mmHg
• 分子式: C₂₈H₃₈N₄O₈
• 分子量: 558.62300
• 闪点: 428.1ºC
• 精确质量: 558.26900
• PSA: 194.68000
• LogP: 1.91870
• InChIKey: WVIUOSJLUCTGFK-JUJPXXQGSA-N
• SMILES: CC(=O)c1cccc(NC2C(N)C(NC(=O)N(C)C)(C(C)O)C(C)(O)C2(O)COC(=O)c2c(C)cccc2O)c1
• 蒸汽压: 6.66E-26mmHg at 25°C
• 折射率: 1.645

密旋霉素毒性和生态

密旋霉素安全信息

• 符号: GHS06
• 信号词: Danger
• 危害声明: H300-H315-H319-H335
• 警示性声明: P261-P264-P301 + P310-P305 + P351 + P338
• 危险品运输编码: UN 2811 6.1 / PGII

密旋霉素靶点实验

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实验名称：Antibacterial activity against Acinetobacter baumannii clinical isolate after 20 hrs ... 来源：ChEMBL 靶标：Acinetobacter baumannii External Id：CHEMBL2344583

实验名称：Antibacterial activity against Enterococcus faecalis ATCC 29212 after 20 hrs by broth... 来源：ChEMBL 靶标：Enterococcus faecalis External Id：CHEMBL2344582

实验名称：Cytotoxicity against human PC3 cells 来源：ChEMBL 靶标：PC-3 External Id：CHEMBL2344581

实验名称：Cytotoxicity against human HCT116 cells 来源：ChEMBL 靶标：HCT-116 External Id：CHEMBL2344580

实验名称：Antibacterial activity against Escherichia coli ATCC 25922 after 20 hrs by broth micr... 来源：ChEMBL 靶标：Escherichia coli External Id：CHEMBL2344587

实验名称：Antibacterial activity against Staphylococcus aureus ATCC 25923 after 20 hrs by broth... 来源：ChEMBL 靶标：Staphylococcus aureus External Id：CHEMBL2344586

实验名称：Antibacterial activity against Klebsiella pneumoniae ATCC 700603 after 20 hrs by brot... 来源：ChEMBL 靶标：Klebsiella pneumoniae External Id：CHEMBL2344585

实验名称：Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 after 20 hrs by brot... 来源：ChEMBL 靶标：Pseudomonas aeruginosa External Id：CHEMBL2344584

实验名称：Toxicity in orally dosed mouse 来源：ChEMBL 靶标：Mus musculus External Id：CHEMBL1005181

实验名称：Antimalarial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR Green-ba... 来源：ChEMBL 靶标：Plasmodium falciparum External Id：CHEMBL2344575

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密旋霉素英文别名

• Pactamycin