SLF TFA
Modify Date: 2024-01-24 19:26:21
SLF TFA structure
|
Common Name | SLF TFA | ||
|---|---|---|---|---|
| CAS Number | 2378802-47-0 | Molecular Weight | 638.67 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C32H41F3N2O8 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SLF TFASLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3]. |
| Name | SLF TFA |
|---|
| Description | SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation[3]. |
| References |
[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425. |
| Molecular Formula | C32H41F3N2O8 |
|---|---|
| Molecular Weight | 638.67 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SLF TFA
- Price: Negotiable
- Purity: 95.0%
- Delivery: 10 Day
- Contact: Tom
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: SLF TFA
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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Price: ￥1050/10 mM * 1 mL in DMSO
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