2378802-47-0
2378802-47-0 structure
- Name: SLF TFA
- Chemical Name: SLF TFA
- CAS Number: 2378802-47-0
- Molecular Formula: C32H41F3N2O8
- Molecular Weight: 638.67
- Create Date: 2021-09-12 18:33:23
- Modify Date: 2024-01-24 19:26:21
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SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3].
| Name | SLF TFA |
|---|
| Description | SLF TFA is a synthetic ligand for FK506-binding protein (FKBP) with an affinity of 3.1 μM for FKBP51 and an IC50 of 2.6 μM for FKBP12. SLF TFA can be used in the synthesis of PROTAC[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Three scout fragments-KB02, KB03, and KB05 are fused, which cover two different electrophile groups (chloroacetamide and acrylamide) and display broad cysteine reactivity in the human proteome-to the SLF ligand that binds tightly and selectively to FKBP12, a cytosolic prolyl isomerase that has been frequently used to study ligand-induced protein degradation[3]. |
| References |
[1]. Kolos JM, et al. FKBP Ligands-Where We Are and Where to Go? Front Pharmacol. 2018 Dec 5;9:1425. |
| Molecular Formula | C32H41F3N2O8 |
|---|---|
| Molecular Weight | 638.67 |