Bradykinin Fragment 1-5

Modify Date: 2024-01-04 12:14:36

Bradykinin Fragment 1-5 structure	Common Name	Bradykinin Fragment 1-5
	CAS Number	23815-89-6	Molecular Weight	572.65600
	Density	1.46g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₇H₄₀N₈O₆	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of Bradykinin Fragment 1-5

Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).

Name	2-[[2-[[1-[1-[2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoic acid
Synonym	More Synonyms

Description	Bradykinin (1-5) is a major stable metabolite of Bradykinin, formed by the proteolytic action of angiotensin-converting enzyme (ACE).
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor Peptides Research Areas >> Cardiovascular Disease
In Vivo	Bradykinin is a short-lived vasoactive peptide, with a reported half-life in vivo of 17 s, that is rapidly metabolized in the circulation to Bradykinin (1-5). Bradykinin (1-5), the product of two sequential cleavages of Bradykinin by ACE at the Pro7-Phe8 and Phe5-Ser6bonds, has been identified as the major stable metabolite of Bradykinin in vivo in human subjects, with a terminal half-life of minutes. Both Bradykinin and Bradykinin (1-5) inhibit α- and γ-thrombin-induced platelet aggregation (P<0.01 versus baseline). Bradykinin (1-5) inhibits γ-thrombin-induced platelet aggregation 50% at a calculated dose of 183±3 pmol/min. Neither Bradykinin nor Bradykinin (1-5) affects thrombin receptor-activating peptide-induced platelet aggregation, consistent with the hypothesis that Bradykinin and Bradykinin 1-5 inhibit thrombin-induced platelet aggregation by preventing cleavage of the thrombin receptor and liberation of thrombin receptor-activating peptide. Bradykinin (1-5) significantly attenuates α-thrombin-induced platelet aggregation but not TRAP 1-6-induced platelet aggregation. Bradykinin (1-5) potently inhibits γ-thrombin (500 nM)-induced platelet aggregation with an ED50 of 183±2 pmol/min[1].
References	[1]. Murphey LJ, et al. Bradykinin and its metabolite Bradykinin 1-5 inhibit thrombin-induced platelet aggregation in humans. J Pharmacol Exp Ther. 2006 Sep;318(3):1287-92.

Density	1.46g/cm3
Molecular Formula	C₂₇H₄₀N₈O₆
Molecular Weight	572.65600
Exact Mass	572.30700
PSA	224.04000
LogP	1.03610
Index of Refraction	1.677
Storage condition	-20°C

Bradykinin Fragment 1-5 MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	F+
RIDADR	NONH for all modes of transport
WGK Germany	3.0

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Arg-pro-pro-gly-phe

Bradykinin Fragment-1-5

2-[2-({1-[1-(2-amino-5-carbamimidamidopentanoyl)pyrrolidine-2-carbonyl]pyrrolidin-2-yl}formamido)acetamido]-3-phenylpropanoic acid

Bradykinin: 1-5

Bradykinin (1-5)