2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole

Modify Date: 2024-01-07 20:27:51

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure
2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole structure
Common Name 2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
CAS Number 24068-15-3 Molecular Weight 229.06300
Density 1.4g/cm3 Boiling Point 343.8ºC at 760mmHg
Molecular Formula C9H6Cl2N2O Melting Point 81-85ºC
MSDS USA Flash Point 161.7ºC

 Names

Name 2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.4g/cm3
Boiling Point 343.8ºC at 760mmHg
Melting Point 81-85ºC
Molecular Formula C9H6Cl2N2O
Molecular Weight 229.06300
Flash Point 161.7ºC
Exact Mass 227.98600
PSA 38.92000
LogP 3.12880
Vapour Pressure 0.000136mmHg at 25°C
Index of Refraction 1.574

 MSDS

Name: 2-Chloromethyl-5-(4-Chlorophenyl)-1 2 4-Oxadiazole 98% Material Safety Data Sheet
Synonym: None Known
CAS: 24068-15-3
Section 1 - Chemical Product MSDS Name:2-Chloromethyl-5-(4-Chlorophenyl)-1 2 4-Oxadiazole 98% Material Safety Data Sheet
Synonym:None Known

Section 2 - COMPOSITION, INFORMATION ON INGREDIENTS
CAS# Chemical Name content EINECS#
24068-15-3 2-Chloromethyl-5-(4-Chlorophenyl)-1,2, 98% unlisted
Hazard Symbols: XI
Risk Phrases: 36/37/38

Section 3 - HAZARDS IDENTIFICATION
EMERGENCY OVERVIEW
Irritating to eyes, respiratory system and skin.
Potential Health Effects
Eye:
Causes eye irritation. May cause chemical conjunctivitis.
Skin:
Causes skin irritation. May be harmful if absorbed through the skin.
Ingestion:
May cause gastrointestinal irritation with nausea, vomiting and diarrhea.
Inhalation:
Causes respiratory tract irritation. Can produce delayed pulmonary edema.
Chronic:
Effects may be delayed.

Section 4 - FIRST AID MEASURES
Eyes: Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Skin:
Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Ingestion:
Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water. Wash mouth out with water.
Inhalation:
Remove from exposure and move to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. Do NOT use mouth-to-mouth resuscitation.
Notes to Physician:
Treat symptomatically and supportively.

Section 5 - FIRE FIGHTING MEASURES
General Information:
As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear. During a fire, irritating and highly toxic gases may be generated by thermal decomposition or combustion.
Extinguishing Media:
Use water spray, dry chemical, carbon dioxide, or chemical foam.

Section 6 - ACCIDENTAL RELEASE MEASURES
General Information: Use proper personal protective equipment as indicated in Section 8.
Spills/Leaks:
Vacuum or sweep up material and place into a suitable disposal container. Clean up spills immediately, observing precautions in the Protective Equipment section. Avoid generating dusty conditions.
Provide ventilation.

Section 7 - HANDLING and STORAGE
Handling:
Avoid breathing dust, vapor, mist, or gas. Avoid contact with eyes, skin, and clothing. Avoid contact with skin and eyes. Keep container tightly closed. Avoid ingestion and inhalation. Use with adequate ventilation. Wash clothing before reuse.
Storage:
Store in a cool, dry place. Store in a tightly closed container.

Section 8 - EXPOSURE CONTROLS, PERSONAL PROTECTION
Engineering Controls:
Facilities storing or utilizing this material should be equipped with an eyewash facility and a safety shower. Use adequate ventilation to keep airborne concentrations low.
Exposure Limits CAS# 24068-15-3: Personal Protective Equipment Eyes: Wear appropriate protective eyeglasses or chemical safety goggles as described by OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard EN166.
Skin:
Wear appropriate protective gloves to prevent skin exposure.
Clothing:
Wear appropriate protective clothing to prevent skin exposure.
Respirators:
Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.

Section 9 - PHYSICAL AND CHEMICAL PROPERTIES

Physical State: Crystalline powder
Color: light yellow
Odor: Not available.
pH: Not available.
Vapor Pressure: Not available.
Viscosity: Not available.
Boiling Point: Not available.
Freezing/Melting Point: 81- 85 deg C
Autoignition Temperature: Not available.
Flash Point: Not available.
Explosion Limits, lower: Not available.
Explosion Limits, upper: Not available.
Decomposition Temperature:
Solubility in water:
Specific Gravity/Density:
Molecular Formula: C9H6Cl2N2O
Molecular Weight: 228.9608

Section 10 - STABILITY AND REACTIVITY
Chemical Stability:
Stable at room temperature in closed containers under normal storage and handling conditions.
Conditions to Avoid:
Dust generation, excess heat.
Incompatibilities with Other Materials:
Oxidizing agents.
Hazardous Decomposition Products:
Hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide.
Hazardous Polymerization: Has not been reported

Section 11 - TOXICOLOGICAL INFORMATION
RTECS#:
CAS# 24068-15-3 unlisted.
LD50/LC50:
Not available.
Carcinogenicity:
2-Chloromethyl-5-(4-Chlorophenyl)-1,2,4-Oxadiazole - Not listed by ACGIH, IARC, or NTP.

Section 12 - ECOLOGICAL INFORMATION


Section 13 - DISPOSAL CONSIDERATIONS
Dispose of in a manner consistent with federal, state, and local regulations.

Section 14 - TRANSPORT INFORMATION

IATA
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
IMO
Shipping Name: Not regulated.
Hazard Class:
UN Number:
Packing Group:
RID/ADR
Not regulated as a hazardous material.

Section 15 - REGULATORY INFORMATION

European/International Regulations
European Labeling in Accordance with EC Directives
Hazard Symbols: XI
Risk Phrases:
R 36/37/38 Irritating to eyes, respiratory system
and skin.
Safety Phrases:
S 26 In case of contact with eyes, rinse immediately
with plenty of water and seek medical advice.
S 37/39 Wear suitable gloves and eye/face
protection.
WGK (Water Danger/Protection)
CAS# 24068-15-3: No information available.
Canada
None of the chemicals in this product are listed on the DSL/NDSL list.
CAS# 24068-15-3 is not listed on Canada's Ingredient Disclosure List.
US FEDERAL
TSCA
CAS# 24068-15-3 is not listed on the TSCA inventory.
It is for research and development use only.


SECTION 16 - ADDITIONAL INFORMATION
N/A

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S37/39
HS Code 2934999090

 Synthetic Route

~79%

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure

2-(chloromethyl...

CAS#:24068-15-3

Literature: OSLO UNIVERSITY HOSPITAL HF; HOLSWORTH, Dan; WAALER, Jo; MACHON, Ondrej; KRAUSS, Stefan; GOLDING, Louise Patent: WO2010/139966 A1, 2010 ; Location in patent: Page/Page column 89-90 ;

~92%

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure

2-(chloromethyl...

CAS#:24068-15-3

Literature: Padmavathi; Dinneswara Reddy; Nagi Reddy; Mahesh European Journal of Medicinal Chemistry, 2011 , vol. 46, # 4 p. 1367 - 1373

~%

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure

2-(chloromethyl...

CAS#:24068-15-3

Literature: Journal of Agricultural and Food Chemistry, , vol. 51, # 1 p. 152 - 155

~%

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure

2-(chloromethyl...

CAS#:24068-15-3

Literature: Journal of Agricultural and Food Chemistry, , vol. 51, # 1 p. 152 - 155

~%

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure

2-(chloromethyl...

CAS#:24068-15-3

Literature: Heterocyclic Communications, , vol. 8, # 6 p. 601 - 606

~52%

2-(chloromethyl)-5-(4-chlorophenyl)-1,3,4-oxadiazole Structure

2-(chloromethyl...

CAS#:24068-15-3

Literature: Natero, Reina; Koltun, Dmitry O.; Zablocki, Jeffery A. Synthetic Communications, 2004 , vol. 34, # 14 p. 2523 - 2529

 Customs

HS Code 2934999090
Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

2-(p-Chlorphenyl)-5-chlormethyl-1,3,4-oxadiazol
5-(4-chlorophenyl)-2-chloromethyl-1,3,4-oxadiazole
2-chloromethyl-5-(4-chloro-phenyl)-[1,3,4]oxadiazole
MFCD00714902
5-(chloromethyl)-2-(4-chlorophenyl)-1,3,4-oxadiazole