MS33

Modify Date: 2024-01-09 18:29:43

MS33 Structure
MS33 structure
Common Name MS33
CAS Number 2407449-11-8 Molecular Weight 1208.48
Density N/A Boiling Point N/A
Molecular Formula C64H84F3N11O7S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MS33


MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].

 Names

Name MS33

 MS33 Biological Activity

Description MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].
Related Catalog
Target

VHL

WDR5:120 nM (Kd)

VCB:870 nM (Kd)

In Vitro MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells Concentration: 0.05, 0.1, 0.5, 1, 5 μM Incubation Time: 1, 2, 4, 8, 16, 24 hours Result: Concentration- and time-dependently induced WDR5 degradation. The DC50 of MS33 was 260 nM, and the maximum degradation of 71%.
References

[1]. Yu X, et, al. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med. 2021 Sep 29;13(613):eabj1578.

 Chemical & Physical Properties

Molecular Formula C64H84F3N11O7S
Molecular Weight 1208.48