2407449-11-8

2407449-11-8 structure

Name: MS33
Chemical Name: MS33
CAS Number: 2407449-11-8
Molecular Formula: C₆₄H₈₄F₃N₁₁O₇S
Molecular Weight: 1208.48
Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
Create Date: 2022-02-20 15:52:00
Modify Date: 2024-01-09 18:29:43
MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].

Name	MS33

Description	MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> Histone Methyltransferase Signaling Pathways >> PROTAC >> PROTAC
Target	VHL WDR5:120 nM (Kd) VCB:870 nM (Kd)
In Vitro	MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells Concentration: 0.05, 0.1, 0.5, 1, 5 μM Incubation Time: 1, 2, 4, 8, 16, 24 hours Result: Concentration- and time-dependently induced WDR5 degradation. The DC50 of MS33 was 260 nM, and the maximum degradation of 71%.
References	[1]. Yu X, et, al. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med. 2021 Sep 29;13(613):eabj1578.

Molecular Formula	C₆₄H₈₄F₃N₁₁O₇S
Molecular Weight	1208.48