2407449-11-8
2407449-11-8 structure
- Name: MS33
- Chemical Name: MS33
- CAS Number: 2407449-11-8
- Molecular Formula: C64H84F3N11O7S
- Molecular Weight: 1208.48
- Catalog: Signaling Pathways Epigenetics Histone Methyltransferase
- Create Date: 2022-02-20 15:52:00
- Modify Date: 2024-01-09 18:29:43
-
MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3].
| Name | MS33 |
|---|
| Description | MS33 is a potent WDR5 degrader, with Kds of 870 nM and 120 nM for VCB and WDR5, respectively. MS33 induces WDR5 degradation in an E3 ligase VHL, and proteasome-dependent manner. MS33 can be used for the research of acute myeloid leukemia[1][2][3]. |
|---|---|
| Related Catalog | |
| Target |
VHL WDR5:120 nM (Kd) VCB:870 nM (Kd) |
| In Vitro | MS33 (0.05-5 μM; 18 h) induces WDR5 degradation in a concentration-dependent manner in MV4;11 cells[1]. Western Blot Analysis[1] Cell Line: MV4;11 cells Concentration: 0.05, 0.1, 0.5, 1, 5 μM Incubation Time: 1, 2, 4, 8, 16, 24 hours Result: Concentration- and time-dependently induced WDR5 degradation. The DC50 of MS33 was 260 nM, and the maximum degradation of 71%. |
| References |
| Molecular Formula | C64H84F3N11O7S |
|---|---|
| Molecular Weight | 1208.48 |