Anticancer agent 127

Modify Date: 2024-01-19 18:14:01

Anticancer agent 127 Structure
Anticancer agent 127 structure
Common Name Anticancer agent 127
CAS Number 2410953-19-2 Molecular Weight 552.66
Density N/A Boiling Point N/A
Molecular Formula C26H37FN4O6S Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Anticancer agent 127


Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].

 Names

Name Anticancer agent 127

 Anticancer agent 127 Biological Activity

Description Anticancer agent 127 (142D6) is an IAP inhibitor that covalently targets the BIR3 domains of XIAP, cIAP1, and cIAP2. Anticancer agent 127 targets the BIR3 domains of XIAP, cIAP1, and cIAP2 with IC50s of 12 nM, 14 nM, and 9 nM, respectively. Anticancer agent 127 has anticancer effects[1].
Related Catalog
Target

IC50: 12 nM (XIAP-BIR3), 14 nM (cIAP1-BIR3), and 9 nM (cIAP2-BIR3)[1]

References

[1]. Udompholkul P, et al. Characterization of a Potent and Orally Bioavailable Lys-Covalent Inhibitor of Apoptosis Protein (IAP) Antagonist. J Med Chem. 2023 Jun 22;66(12):8159-8169.  

 Chemical & Physical Properties

Molecular Formula C26H37FN4O6S
Molecular Weight 552.66